Protein Alignment Cyp6a21 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0033981
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 127/529 - (24%)
• Similarity: 226/529 - (42%)
• Gaps: 64/529 - (12%)

  Fly     4 GTVLLTALLALVGYLLMKWRSTMRHWQDL-----GIPCEEPHILMGSMKGVRTARSFNEIWTSYY 63
            |.:.:|:||.|: .||:|......|.|.|     ..||...|.|.|.::..:..:....| ....
Human    17 GILQVTSLLILL-LLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRI-QERV 79

  Fly    64 NKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQLFLLDGQKW 128
            ..|..:.|:  :.|..:..|.:.:....|.||.:...|......|..|.   :...|.||:||.|
Human    80 KTFPSACPY--WIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR---IGYGLLLLNGQTW 139

  Fly   129 RTMRNKLSSTFTSGKMK----YMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTC 189
            ...|..|:..|.:..:|    .|..:|..:.:::.::.||:   || :||.:.::..|.|.|...
Human   140 FQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD---SP-LEVFQHVSLMTLDTIMKS 200

  Fly   190 AFGIECSSLKDPDAE----------------FREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHM 238
            ||..:.|...|.:::                .|.....:.|...|...|     .:.:.|.:|..
Human   201 AFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAG-----RWTHRACQLAH 260

  Fly   239 KMTAEPIERFFMRIVRETVAFREQNNIRRN---DFMDQLIDLKNKPLMVSQSGESVNLTIEEIAA 300
            :.|.:.|:....::.:|    .|...|:|.   ||:|.|       |:......|: |:.:::.|
Human   261 QHTDQVIQLRKAQLQKE----GELEKIKRKRHLDFLDIL-------LLAKMENGSI-LSDKDLRA 313

  Fly   301 QAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVS 365
            :...|...|.:|:::.:.:.||.||.:...|.|.|:|...::.. ...:.:..:..:.|....:.
Human   314 EVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD-GASITWNHLDQMPYTTMCIK 377

  Fly   366 ETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPER 430
            |.||||..:|.:.||.......|....  :.||:.||:....:|.:.|::.|...|:|..|:|..
Human   378 EALRLYPPVPGIGRELSTPVTFPDGRS--LPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGS 440

  Fly   431 VKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNS 495
            .:.  |..:|||..|.|||||.:|...|.::..||.:..|:. :.:.|.||:...:  .::.|.:
Human   441 AQH--SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL-LPDPTRIPIPMAR--LVLKSKN 500

  Fly   496 GIYLKAERV 504
            ||:|:..|:
Human   501 GIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	114/486 (23%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	114/487 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900