DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	502	Identity:	120/502 - (23%)
Similarity:	214/502 - (42%)	Gaps:	74/502 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PCEEPHILMGSMKGVR--TARSFNEIWTSYYNKFR-GSGPFAGFYWFRRP--AVFVLETSLAKQI 94
            |....|..:|..|.::  ......||...|...|. ..|||..|:....|  |..:|..:..|..
Human    47 PAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQ 111

  Fly    95 LIKEFNKFTDRGFFHNPEDDPLSGQ-LFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEF 158
            .:::|:             .||.|: |..|||.||...|..|:..|....:|.....:.......
Human   112 YLQKFS-------------PPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMM 163

  Fly   159 TDVFGQNVA-KSPVVEVRELLARFTTDVIGTCAFGIE--C--SSLKDPDAE---------FREMG 209
            .|.:.:..: :...|||.|.:...:.|:|..|||..|  |  :|..||.|:         |..:
Human   164 LDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRL- 227

  Fly   210 RRSLTEQ-----RLGPVGIGFVNSFPNLARRLHMKMTAEPIERFFMRIVRE-----TVAFREQNN 264
             .||...     :|.|.|.    .|..|:|.|:         ::...|::|     ....::.|.
Human   228 -YSLLYHSDIIFKLSPQGY----RFQKLSRVLN---------QYTDTIIQERKKSLQAGVKQDNT 278

  Fly   265 IRR--NDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQN 327
            .:|  .||:|.::..|:      :||.|  .:..::.::...|..||.:|.:.::.:.||.||.|
Human   279 PKRKYQDFLDIVLSAKD------ESGSS--FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALN 335

  Fly   328 QDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPK 392
            .:.|.|.|:|.:.::.. ...:.::.:.::.|....:.||.||...:|.::|:..:....|  ..
Human   336 PEHQERCREEVRGILGD-GSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP--DG 397

  Fly   393 YVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQM 457
            ..:..|:.|::....:|.:..::.||..|:|..||.|...:|....:|||..|.|||||..|..:
Human   398 CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMI 462

  Fly   458 QARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGIYLKAERV 504
            :.::.:||::..|:  |....|.|:|:... |::...:|:||..:::
Human   463 ELKVTIALILLHFR--VTPDPTRPLTFPNH-FILKPKNGMYLHLKKL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	118/495 (24%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	118/495 (24%)
CYP4X1	NP_828847.1	heme binding region	447..460		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810