Protein Alignment Cyp6a21 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0288232
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 512
• Identity: 158/512 - (30%)
• Similarity: 255/512 - (49%)
• Gaps: 55/512 - (10%)

  Fly     1 MSVGTVLLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEP--------HILMGSMK-GVRTARS 54
            :|..|:....|||:|..||..: .|..|  ::..|||..:|        :..||..| .|...:.
  Rat     4 LSALTLETWVLLAVVLVLLYGF-GTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKFDVECHKK 67

  Fly    55 FNEIWTSYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDDP--- 115
            :.:||          |.|.|    :.|...:.:|.:.|.:|:|| |:.||:|..|     .|
  Rat    68 YGKIW----------GLFDG----QMPLFAITDTEMIKNVLVKECFSVFTNRRDF-----GPVGI 113

  Fly   116 LSGQLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLAR 180
            :...:.:...::|:..|..||.|||||::|.|||.:.:..:.......|.  |...|.|:|:...
  Rat   114 MGKAISVSKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE--KGKPVPVKEVFGA 176

  Fly   181 FTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMTA 242
            ::.|||.:.:||:...||.:|...|.|..::.|......|:.:..| .||.|.   ..|::.|..
  Rat   177 YSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVV-LFPFLTPVYEMLNICMFP 240

  Fly   243 EPIERFFMRIV---RETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGES-VNLTIEEIAAQAF 303
            :....||.:.|   :||.....|.:  |.||:..:::..|.    |:..|| ..|:..||.||:.
  Rat   241 KDSIEFFKKFVYRMKETRLDSVQKH--RVDFLQLMMNAHND----SKDKESHTALSDMEITAQSI 299

  Fly   304 VFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETL 368
            :|..||:|.:|:|:.|.|:.||.:.|.|.::::|....:.. .....|:::.::.|||.|::|||
  Rat   300 IFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPN-KAPPTYDTVMEMEYLDMVLNETL 363

  Fly   369 RLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKE 433
            |||.:...|.|.|.:|.|:.|   ..:.||..|:||..|:|||.:.:..|..|.|:.||.|....
  Rat   364 RLYPIGNRLERVCKKDVEING---VFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGS 425

  Fly   434 RDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFL 490
            .|...:||||:||||||||||..|..::.|..::::|.|..|::|.||:..:::..|
  Rat   426 IDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	CYP6-like	68..498	CDD:410679	138/434 (32%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	140/448 (31%)