DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	147/507 - (28%)
Similarity:	257/507 - (50%)	Gaps:	53/507 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVGTVLLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSMKGVRTARSFN---EIWT 60
            :|:.|.:|.|...::.|:.    .|..|  ::.||||..:|..|.|::        ||   .:|.
  Rat     7 LSIETWVLLATSLMLFYIY----GTYSHGLFKKLGIPGPKPVPLFGTI--------FNYGDGMWK 59

  Fly    61 SYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDR------GFFHNPEDDPLSG 118
            ...:.::..|...|||...:|.:.:::..:.|.:|:|| ::.||:|      ||        :..
  Rat    60 FDDDCYKKYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGF--------MKK 116

  Fly   119 QLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNV----AKSPVVEVRELLA 179
            .:.:.:.::|:.:|..||.||||||:|.|||    :..::.|...:|:    ||...:.::::..
  Rat   117 AITMSEDEEWKRLRTILSPTFTSGKLKEMFP----LMRQYGDTLLKNLRREEAKGEPINMKDIFG 177

  Fly   180 RFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMT 241
            .::.|||...:||:...||.:|...|.:..::.|..|...|..:..| .||.|.   ..|:..:.
  Rat   178 AYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVV-LFPFLTPIYEMLNFSIF 241

  Fly   242 AEPIERFFMRIVRETVAFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVF 305
            ......||.:.|:.....| :.|...|.||:..:::.:|.....||..    |:..|:||||.:|
  Rat   242 PRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKA----LSDLEMAAQAIIF 302

  Fly   306 FAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRL 370
            ...|::.:||::.|.:||||...::|.:::.|....:.. ...:.|:::.::.|||.||:|:|||
  Rat   303 IFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPN-KAPVTYDALMEMEYLDMVVNESLRL 366

  Fly   371 YTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERD 435
            |.:...|:|...:|.|:.|   ..|.||..|.||...:||:.:.:..|..|||:.||.|.....|
  Rat   367 YPIATRLDRVSKKDVEING---VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSID 428

  Fly   436 SVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKE 487
            ...:||||:||||||||||..:..::.:..::::|....||||.||:..:::
  Rat   429 PYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQ 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	137/471 (29%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	130/435 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770