DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	155/536 - (28%)
Similarity:	255/536 - (47%)	Gaps:	58/536 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GTVLLTALLALVGYLLMKWRST--MRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKF 66
            ||| :|..|::|...|:||.||  ....:.|||...||...:|::...|..     .|.|:....
  Rat    13 GTV-VTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQG-----FWESHLELR 71

  Fly    67 RGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQLFLLDGQKWRTM 131
            ...||..|:|..||..:.:.:..:.|::|::.|:.|::| .....|...::..:.:|..::|..:
  Rat    72 ERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNR-MASGLEPKLIADSVLMLRDRRWEEV 135

  Fly   132 RNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCAFGIECS 196
            |..|.|.|:..|:..|.|.:.:...........:.|.....:::.....|||:|:.:.|||||.:
  Rat   136 RGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVN 200

  Fly   197 SLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPN----LARRLHMKMTAEPIERFFMRIVRETV 257
            |...|:..|.:..:|........|: :..:.|||:    |||.|..| ..:.:..||..::|..:
  Rat   201 SQDAPEDPFVQHCQRVFAFSTPRPL-LALILSFPSIMVPLARILPNK-NRDELNGFFNTLIRNVI 263

  Fly   258 AFREQNNI--RRNDFMDQLIDLKNKPL--------MVSQSGESVN-----------------LTI 295
            |.|::...  ||.||:..::|.:....        ||:::..|..                 ||:
  Rat   264 ALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTV 328

  Fly   296 EEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEK------CNGELNYESM 354
            :|||.|||:|..||.|.::.|:.|..|.||.:.:.|.|:.||....:||      ||      ..
  Rat   329 DEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCN------LQ 387

  Fly   355 KDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPN 419
            :.|.|||.||:||||:|.......||..:|.||.|..   |..|..:.|..||:|.|.:.:.||.
  Rat   388 EGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQH---IPAGSVLEIAVGALHHDPEHWPNPE 449

  Fly   420 TFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTY 484
            ||:|:.|:.|...::....:||||.|||:|:|:|.|.:..::.|..::..|:|..|.:|.:|:..
  Rat   450 TFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQL 514

  Fly   485 NKEMFLIASNSGIYLK 500
            ..:..|...| |:|:|
  Rat   515 ESKSALCPKN-GVYVK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	139/500 (28%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	141/501 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770