DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a21 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	120/532 - (22%)
Similarity:	217/532 - (40%)	Gaps:	90/532 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGSG 70
            :|:..:|.|...||.  |..:....| ..|....|.|.|....::...|.::: .|:..:|
  Rat    21 ILMVIVLKLFSLLLR--RQKLARAMD-SFPGPPTHWLFGHALEIQKLGSLDKV-VSWAQQF---- 77

  Fly    71 PFAGFYWFRRPAVF--VLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQ------------LF 121
            |.|...||.:...|  :.|...||.:.        .||       ||.:..            |.
  Rat    78 PHAHPLWFGQFVGFLNIYEPDYAKAVY--------SRG-------DPKAADVYDFFLQWIGKGLL 127

  Fly   122 LLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVI 186
            :|||.||...|..|:..|....:|.......:......|.:.:..:::...::...:.....|.:
  Rat   128 VLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTL 192

  Fly   187 GTCAFGIECSSLKDPDAEFREMGRRSLT---EQRLGPVGIGFVNSFPNLARRLHMKMT--AEPIE 246
            ..|.||...|.|...|..: .:....||   :||        ::||     :.|....  ..|..
  Rat   193 MKCTFGKGDSGLGHRDNSY-YLAVSDLTLLMQQR--------IDSF-----QYHNDFIYWLTPHG 243

  Fly   247 RFFMR-----------IVRETVAF----REQNNI---RRNDFMDQLIDLKNKPLMVSQSGESVNL 293
            |.|:|           ::|:..|.    :|:..|   |..||:|.|:.:::      :||  :.|
  Rat   244 RRFLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQRRHLDFLDILLGVRD------ESG--IKL 300

  Fly   294 TIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLV 358
            :..|:.|:...|...|.:|:::.:.:.||.:|...:.|...|:|.:.::.. .....::.:..:.
  Rat   301 SDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGD-QDSFQWDDLAKMT 364

  Fly   359 YLDQVVSETLRLYTVLPVLNRECLEDYE-VPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFN 422
            ||...:.|..|||..:|.:.|:..:... |.|..   :..|..:.:...|:||:..::.:|..|:
  Rat   365 YLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRS---LPAGSLISLHIYALHRNSTVWPDPEVFD 426

  Fly   423 PDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKE 487
            |..||||....|....::||..|||||||.:|...:.::..||.:..|:||: :.:.:|:  ...
  Rat   427 PLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSL-DPSKMPI--KVP 488

  Fly   488 MFLIASNSGIYL 499
            ..::.|.:||:|
  Rat   489 QLILRSKNGIHL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	112/501 (22%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	112/501 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900