DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and CYP4Z1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_835235.1	Gene:	CYP4Z1 / 199974	HGNCID:	20583	Length:	505	Species:	Homo sapiens

Alignment Length:	533	Identity:	122/533 - (22%)
Similarity:	221/533 - (41%)	Gaps:	84/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGS 69
            ::||..::.|  |...:|.....|.    .|....|...|. |.....:.| |::.....|:..:
Human    23 SLLLFQVIRL--YQRRRWMIRALHL----FPAPPAHWFYGH-KEFYPVKEF-EVYHKLMEKYPCA 79

  Fly    70 -----GPFAGFYWFRRP--AVFVLETSLAKQ-ILIKEFNKFTDRGFFHNPEDDPLSGQLFLLDGQ 126
                 |||..|:....|  |..:|:....|. :..|....:..||             |..|||.
Human    80 VPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRG-------------LVTLDGS 131

  Fly   127 KWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCAF 191
            ||:..|..:...|....:|.....:.:......:.:.:::|::..:|:.:.::..|.|.|..|||
Human   132 KWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAF 196

  Fly   192 GIECSSLKDP--DAEFREMGRRS-LTEQRLGPVGIGFVNSFPNLARRLH-----MKMTAEPIERF 248
            ..:.|...|.  |:..:.:...| ::.||:        |:|      ||     .|.:::  .:.
Human   197 SHQGSIQLDSTLDSYLKAVFNLSKISNQRM--------NNF------LHHNDLVFKFSSQ--GQI 245

  Fly   249 FMRIVRETVAFREQ-----------------NNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIE 296
            |.:..:|...|.|:                 ...||.||:|.|:..|        |..:.:.:..
Human   246 FSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAK--------SENTKDFSEA 302

  Fly   297 EIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLD 361
            ::.|:...|..||.:|:|:.:.:.||.||:..:.|.|.|.|.:|::.. ...:.:|.:..:.|..
Human   303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSSITWEHLSQMPYTT 366

  Fly   362 QVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNF 426
            ..:.|.||||.  ||:|...|.|..:.......:..|:.|.|...|:|.:...:.:|..|||..|
Human   367 MCIKECLRLYA--PVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRF 429

  Fly   427 SPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLI 491
            |.|..::.....::||..|.|||||..|..::.::.:||.:..||.:. :.:..|....:  .::
Human   430 SRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP-DHSRPPQPVRQ--VVL 491

  Fly   492 ASNSGIYLKAERV 504
            .|.:||::.|::|
Human   492 KSKNGIHVFAKKV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	114/496 (23%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	114/497 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900