DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	155/503 - (30%)
Similarity:	260/503 - (51%)	Gaps:	51/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGSGP 71
            |.||.::..:|:....|..|  ::.||||..:|...:|::...|  :.|.|.....:.|:   |.
  Rat    11 TWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYR--KGFWEFDKYCHKKY---GK 70

  Fly    72 FAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDDP---LSGQLFLLDGQKWRTMR 132
            ..|.|..|:|.:.:.:..:.|.:|:|| ::.||:|..|     .|   |...:.:.:.::|:.:|
  Rat    71 LWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNF-----GPVGILKKAISISEDEEWKRIR 130

  Fly   133 NKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNV----AKSPVVEVRELLARFTTDVIGTCAFGI 193
            ..||.||||||:|.|||    :.|::||:..:|:    .:.....::::...::.|||...:||:
  Rat   131 ALLSPTFTSGKLKEMFP----IINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGV 191

  Fly   194 ECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMTAEPIERFFMRIVRE 255
            ...||.:|...|.|..::.|......|:.:. |..||.|.   ..|::.|....:..||    :.
  Rat   192 NVDSLNNPQDPFVEKIKKLLKFDIFDPLFLS-VTLFPFLTPLFEALNVSMFPRDVIDFF----KT 251

  Fly   256 TVAFREQNNIR-----RNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGFETSST 315
            :|...::|.::     |.||:..:|:.:|..:..|...    |:..||.||:.:|..||:||:|:
  Rat   252 SVERMKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKA----LSDVEIVAQSVIFIFAGYETTSS 312

  Fly   316 TMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRE 380
            .:.|.||.||.:.|||.:::.|....:.. .....|:::..:.|||.||:||||||.:...|.|.
  Rat   313 ALSFVLYLLAIHPDIQKKLQDEIDAALPN-KAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERV 376

  Fly   381 CLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVE---WLPF 442
            |..|.|:.|   ..|.||..|:||..|:|:|...:..|..|.|:.||.   |.:|::.   :|||
  Rat   377 CKTDVEING---VFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSK---KNQDNINPYMYLPF 435

  Fly   443 GDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFL 490
            |:||||||||||..|..::.|..::::|.|..|::|.||:..:|:..|
  Rat   436 GNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGLL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	146/475 (31%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	146/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770