DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	527	Identity:	115/527 - (21%)
Similarity:	222/527 - (42%)	Gaps:	75/527 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GTVLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRG 68
            |.:|:...|.|: :||:: |.|:....| ..|....|.|.|....::...|.::: .|:.::|
Human    19 GLILVLGFLKLI-HLLLR-RQTLAKAMD-KFPGPPTHWLFGHALEIQETGSLDKV-VSWAHQF-- 77

  Fly    69 SGPFAGFYWFRRPAVF--VLETSLAKQILIKE----------FNKFTDRGFFHNPEDDPLSGQLF 121
              |:|...||.:...|  :.|...||.:..:.          |.::..||             |.
Human    78 --PYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG-------------LL 127

  Fly   122 LLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVI 186
            :|:|.||...|..|:..|....:|.......:......|.:.:...:....::...:.....:.:
Human   128 VLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTL 192

  Fly   187 GTCAFGIECSSL---KDPDAEFREMGRRSLTEQRLGPVGIGFVNSF-----PNLARRLHMKMTAE 243
            ..|.||...:.|   :|............|.:|||  |...:.|.|     |:..|.|.....|.
Human   193 MKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRL--VSFQYHNDFIYWLTPHGRRFLRACQVAH 255

  Fly   244 PIERFFMRIVRETVAFREQNNIRRN-------DFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQ 301
            .   ...:::||..|..:...:|:.       ||:|.|:..:::        :.:.|:..::.|:
Human   256 D---HTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDE--------DDIKLSDADLRAE 309

  Fly   302 AFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDL---VYLDQV 363
            ...|...|.:|:::.:.:.||.:|...:.|:|.|:|.:|::    |:.::....||   .||...
Human   310 VDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL----GDQDFFQWDDLGKMTYLTMC 370

  Fly   364 VSETLRLYTVLPVLNRECLEDYE-VPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFS 427
            :.|:.|||..:|.:.|:..:... |.|..   :..|..:.:...|:||:..::.:|..|:...||
Human   371 IKESFRLYPPVPQVYRQLSKPVTFVDGRS---LPAGSLISMHIYALHRNSAVWPDPEVFDSLRFS 432

  Fly   428 PERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIA 492
            .|...:|....::||..|||||||.:|...:.::..|:.:..|:||: :.:.:|:  .....::.
Human   433 TENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSL-DPSRLPI--KMPQLVLR 494

  Fly   493 SNSGIYL 499
            |.:|.:|
Human   495 SKNGFHL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	105/494 (21%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	105/494 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900