DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	526	Identity:	165/526 - (31%)
Similarity:	269/526 - (51%)	Gaps:	63/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVGTVLLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSMKGVRTARSFNEIW---T 60
            ::|.|.||.|:..::.||.    .|..|  ::.||||...|..|:|::...|..     :|   |
Human     7 LAVETWLLLAVSLVLLYLY----GTRTHGLFKRLGIPGPTPLPLLGNVLSYRQG-----LWKFDT 62

  Fly    61 SYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDR------GFFHNPEDDPLSG 118
            ..|.|:   |...|.|..:.|.:.:.:..:.:.:|:|| ::.||:|      ||        :..
Human    63 ECYKKY---GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF--------MKS 116

  Fly   119 QLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNV----AKSPVVEVRELLA 179
            .:.|.:.::|:.:|:.||.||||||:|.|||.:.    ::.||..:|:    .|...|.::::..
Human   117 AISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIA----QYGDVLVRNLRREAEKGKPVTLKDIFG 177

  Fly   180 RFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMT 241
            .::.|||...:||:...||.:|...|.|..::.|....|.|:.:..: .||.|.   ..|::.:.
Human   178 AYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII-LFPFLTPVFEALNVSLF 241

  Fly   242 AEPIERFFMRIVRETVAFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN-LTIEEIAAQAFV 304
            .:....|..:.|......| ......|.||:..:||.:|     |:..||.. |:..|:|||:.:
Human   242 PKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN-----SKETESHKALSDLELAAQSII 301

  Fly   305 FFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLR 369
            |..||:||:|:.:.|.|||||.:.|:|.:::||...|:.. .....|:::..:.|||.||:||||
Human   302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETLR 365

  Fly   370 LYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKER 434
            |:.|...|.|.|.:|.|:.|   ..|.||..|:||..|:|.|.|.:..|..|.|:.||    |::
Human   366 LFPVAIRLERTCKKDVEING---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS----KKK 423

  Fly   435 DSVE---WLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSG 496
            ||::   :.|||.||||||||||..|..::.|..::::|.|..|::|.||:..:.: .|:.....
Human   424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ-GLLQPEKP 487

  Fly   497 IYLKAE 502
            |.||.:
Human   488 IVLKVD 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	151/485 (31%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	152/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.720