Protein Alignment Cyp6a21 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0033981
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 152/505 - (30%)
• Similarity: 259/505 - (51%)
• Gaps: 71/505 - (14%)

  Fly     9 TALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSM----KG-----VRTARSFNEIWTSY 62
            |.||..|..:|:....|..|  ::.||||...|...:|::    ||     :...:.:.::|
Human    11 TWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVW--- 72

  Fly    63 YNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDR------GFFHNPEDDPLSGQL 120
                       |||..::|.:.:.:..:.|.:|:|| ::.||:|      ||        :...:
Human    73 -----------GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF--------MKSAI 118

  Fly   121 FLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAK-----SPVVEVRELLAR 180
            .:.:.::|:.:|:.||.||||||:|.|.|.:.    ::.||..:|:.:     .||. ::::...
Human   119 SIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIA----QYGDVLVRNLRREAETGKPVT-LKDVFGA 178

  Fly   181 FTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNL---ARRLHMKMTA 242
            ::.|||.:.:||:...||.:|...|.|..::.|....|.|..:. :..||.|   ...|::.:..
Human   179 YSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLS-ITVFPFLIPILEVLNICVFP 242

  Fly   243 EPIERFFMRIVRETVAFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN-LTIEEIAAQAFVF 305
            ..:..|..:.|:.....| |.....|.||:..:||.:|     |:..||.. |:..|:.||:.:|
Human   243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN-----SKETESHKALSDLELVAQSIIF 302

  Fly   306 FAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRL 370
            ..||:||:|:.:.|.:||||.:.|:|.::::|...|:.. .....|:::..:.|||.||:|||||
Human   303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNETLRL 366

  Fly   371 YTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERD 435
            :.:...|.|.|.:|.|:.|   ..|.||:.|:||..|:|||.|.:..|..|.|:.||.   |.:|
Human   367 FPIAMRLERVCKKDVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK---KNKD 425

  Fly   436 SVE---WLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPM 482
            :::   :.|||.||||||||||..|..::.|..::::|.|..|::|.||:
Human   426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	142/477 (30%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	142/477 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820