DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	505	Identity:	157/505 - (31%)
Similarity:	256/505 - (50%)	Gaps:	42/505 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVGTVLLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSMKGVRTARSFNEIW---T 60
            :|:.|::   |||::..||.:: .|..|  ::..|||..:|...:|::     ...:..:|   .
Mouse     7 LSLDTLV---LLAIILVLLYRY-GTCTHGLFKKQGIPGPKPLPFLGTV-----LNYYKGLWKFDM 62

  Fly    61 SYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDR-GFFHNPEDDP---LSGQL 120
            ..|.|:   |...|.:..:.|...:.:....|.:|:|| |:.||:| .||      |   :|..:
Mouse    63 ECYEKY---GKTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFF------PVGIMSKSI 118

  Fly   121 FLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDV 185
            .|...::|:..|..||.|||||.:|.|||.:.:..:.......|...|...|.|:::|..::.||
Mouse   119 SLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDV 183

  Fly   186 IGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHMKMTAEPIER 247
            |.:..||:...||.:|:..|.|..::.|......|:.:. |..||.|.   ..|::.|..:....
Mouse   184 IISTTFGVNIDSLNNPEDPFVENAKKVLRFDYFDPLSLS-VALFPFLTPIYEMLNICMFPKDSIE 247

  Fly   248 FFMRIV-RETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIE-EIAAQAFVFFAAGF 310
            ||.:.| |.|....:.....|.||:..:::..||    |:..:|.....| ||.||:.:|..||:
Mouse   248 FFKKFVDRMTENRLDSKQKHRVDFIYLMMEAYNK----SKDKDSHKALSEIEITAQSIIFIFAGY 308

  Fly   311 ETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLP 375
            ||:|:.:.|.:|.||.:.|||.::::|..|.:.. .....|:::..:.|||.|::||||||.:..
Mouse   309 ETTSSILSFTVYSLATHPDIQKKLQEEIDEALPN-KAPPTYDTVMAMEYLDMVLNETLRLYPITN 372

  Fly   376 VLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWL 440
            .|.|.|.:|.|:.|   ..|.||..|:||...:|.|.:.:..|..|.|:.||.|.....|...:|
Mouse   373 RLQRVCKKDVEING---IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYL 434

  Fly   441 PFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFL 490
            |||:||||||||||..|..::.|..::::|.|..|::|.||:..::|:.|
Mouse   435 PFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRELLL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	146/469 (31%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	146/469 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720