DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	520	Identity:	156/520 - (30%)
Similarity:	259/520 - (49%)	Gaps:	67/520 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVGTVLLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSM----KG-----VRTARS 54
            |....:|.|:|:.|..|      .|..|  ::.||||..:|...:|::    ||     ::..:.
Mouse     9 METWMLLATSLVLLYLY------GTHSHGIFKKLGIPGPKPLPFLGTILAYQKGFWECDIQCHKK 67

  Fly    55 FNEIWTSYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDRGFFHNPEDDP--- 115
            :.::|              |.|..|:|.:.:.:..:.|.:|:|| ::.||:|..|     .|
Mouse    68 YGKMW--------------GLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRF-----GPVGI 113

  Fly   116 LSGQLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQN----VAKSPVVEVRE 176
            |...:.:.:.::|:.:|..||.|||||::|.|||    :.|:||||..:|    :.:.....:::
Mouse   114 LKKAISISENEEWKRIRALLSPTFTSGRLKEMFP----IINQFTDVLVRNMRQGLGEGKPTSMKD 174

  Fly   177 LLARFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLA---RRLHM 238
            :...::.|||...:||:...||.:|...|.|..::.|......|:.:. |..||.|.   ..|::
Mouse   175 IFGAYSMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLS-VTLFPFLTPVFDALNV 238

  Fly   239 KMTAEPIERFFMRIVRETVAFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQA 302
            .:....:..||...|......| ::...:|.||:..:|:.:|.....|...    |:..||.||:
Mouse   239 SLFPRDVISFFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKESHKA----LSDVEIVAQS 299

  Fly   303 FVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSET 367
            .:|..||:||:|:.:.||||.||.:.|:|.:::.|....:.. .....|:::..:.|||.||:||
Mouse   300 VIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPN-KAPATYDTLLQMEYLDMVVNET 363

  Fly   368 LRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVK 432
            ||||.:...|.|.|..|.|:.|   ..|.||..|:||..|:|:|.|.:..|..|.|:.||.   |
Mouse   364 LRLYPIAGRLERVCKTDVEING---LFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSK---K 422

  Fly   433 ERDSVE---WLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASN 494
            .:||:.   :||||.||||||||||..:..::.|..::::|....|::|.||:..:|:..|...|
Mouse   423 NQDSINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLLQPEN 487

Fly 495 494
Mouse 488 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	145/484 (30%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	145/484 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710