DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	518	Identity:	126/518 - (24%)
Similarity:	226/518 - (43%)	Gaps:	85/518 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGSGPFAGFYWFRRPAVF- 84
            ||...:.|   ||:.....|.|......|.|.......|.         ||.........|.:.
Mouse    61 KWNWFLGH---LGMITPTEHGLKEVTNLVATYPQGFMTWL---------GPIIPIITLCHPDIIR 113

  Fly    85 -VLETSLA---KQILIKEFNKFTDRGFFHNPEDDPLSGQ-LFLLDGQKWRTMRNKLSSTFTSGKM 144
             ||..|.:   |:::...|.|             |..|. |.|.||.||.:.|..|:..|....:
Mouse   114 SVLNASASVALKEVVFYSFLK-------------PWLGDGLLLSDGDKWSSHRRMLTPAFHFNIL 165

  Fly   145 KYMFPTVVKVANEFTDVF---GQNVAK--SPVVEVRELLARFTTDVIGTCAFGIECSSLKDPD-- 202
            |    ..||:.|:.|::.   .|::|.  |..::|.|.::..|.|.:..|.|..:.:..::|.
Mouse   166 K----PYVKIFNDSTNIMHAKWQHLASGGSARLDVFENISLMTLDSLQKCVFSFDSNCQENPSEY 226

  Fly   203 -AEFREMGRRSLTEQRLGPVGIGFVNSFPNL---ARRLHMKMTAEPIERFFMRIV---RETVAFR 260
             :...|:.  :|..:|...: :..::|...|   .||.|  .....:..|...::   |.|:..:
Mouse   227 ISAILELS--ALVTKRYHQL-LLHIDSLYQLTCSGRRFH--KACHLVHSFTDAVIQDRRRTLPSK 286

  Fly   261 EQNNI-------RRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMG 318
            .::::       :..||:|        .|::|:..:...|:.|:|.|:|..|...|.:|:::.:.
Mouse   287 HEDDVLKAKAKSKTLDFID--------VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLS 343

  Fly   319 FALYELAQNQDIQNRVRKECQEVIE-------KCN-GELNYESMKDLVYLDQVVSETLRLYTVLP 375
            :.||.||::.:.|.|.|:|.||::.       :|: .....:.:..|.:|...:.|:|||:..:.
Mouse   344 WILYNLARHPEYQERCRQEVQELLRDRESTEIECSCAVFLRDDLAQLPFLTMCIKESLRLHPPVT 408

  Fly   376 VLNRECLEDYEVP-GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEW 439
            |::|.|.:|..:| |.   ||.||:..:|...|.|.:..::.:|..::|..|.||.:|:|..:.:
Mouse   409 VISRRCTQDIVLPDGR---VIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAF 470

  Fly   440 LPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGIYLKAE 502
            :||..|||||||..|...:.::.|||.:  .:|.|......|.  .|...::.:..|::|:.|
Mouse   471 IPFSAGPRNCIGQTFAMNEMKVALALTL--LRFRVLPDDKEPR--RKPELILRAEGGLWLRVE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	119/499 (24%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	124/513 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900