DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a21 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	557	Identity:	121/557 - (21%)
Similarity:	219/557 - (39%)	Gaps:	125/557 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVGTVLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKF 66
            ||..:||..:.|:..||..||                      .:|.::...|....|...:.:|
Mouse    23 SVLGLLLLLVKAVQFYLHRKW----------------------LLKALQQFPSPPFHWFFGHEQF 65

  Fly    67 RGS--------------GPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLS 117
            :|.              ..|..::|.....:.|.:....|.||               ...||.:
Mouse    66 KGEQELKEVVSCIEHFPSAFPCWFWGSNAYLTVYDPDYMKVIL---------------GRSDPKA 115

  Fly   118 GQLF------------LLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANE---FTDVFGQNVA 167
            ..::            ||:||.|...|..|:..|....:|   |.|..:|:.   ..|.:.:...
Mouse   116 NGIYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILK---PYVKNMADSIRLMLDKWERLAG 177

  Fly   168 KSPVVEVRELLARFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNL 232
            :...:|:.:.::..|.|.:..|||..:.|...|        |......|.:|.:.    |.|.:.
Mouse   178 QDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVD--------GNYKTYLQAIGDLN----NLFHSR 230

  Fly   233 ARRL-HMKMTAEPIERFFM--RIVRE-----------TVAFR--------EQNNI---RRNDFMD 272
            .|.: |...|   |.|...  |:.::           .:..|        |..||   ||.||:|
Mouse   231 VRNIFHQNDT---IYRLSSNGRLAKQACQLAHDHTDGVIKMRKDQLQDEGELENIKKKRRLDFLD 292

  Fly   273 QLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKE 337
            .|:..:      .::|:|  ::.:::.|:...|...|.:|:::.:.:..|.||.:.:.|.|.|:|
Mouse   293 ILLFAR------MENGDS--MSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREE 349

  Fly   338 CQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVL 402
            .|.::.. ...:.::.:..:.|....:.|.||||..:|.:.||.......|....  :.||:.|.
Mouse   350 VQSLLGD-GSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRS--LPKGVQVT 411

  Fly   403 IPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLI 467
            :....:|.:.|::.||..|:|..|:|:  ..|.|..:|||..|.|||||.:|...:.::.:||.:
Mouse   412 LSIYGLHHNPKVWPNPEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTL 474

  Fly   468 KDFKFSVCEKTTIPMTYNKEMFLIASNSGIYLKAERV 504
            ..|:. :.:.|.:|....:  .::.|.:||||..:::
Mouse   475 LHFEL-LPDPTRVPEPLAR--IVLKSKNGIYLHLKKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	110/517 (21%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	109/499 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900