Protein Alignment Cyp6a20 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 155/589 - (26%)
• Similarity: 257/589 - (43%)
• Gaps: 121/589 - (20%)

  Fly     3 VMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKRTYNKLRNKT 67
            |.:.|.:.::..:.||....|:..::.|:.|.:|....||.:      .|...|..:..:|| |.
Human    16 VTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLT------FFRQGFWESQMELR-KL 73

  Fly    68 DGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDR---GV-FHNERDDPLSANLVNIDGQKWK 128
            .||..|:|:..:..:|:::.|..|.||:..|..|.:|   |: |.:..|     :::.:..::|:
Human    74 YGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD-----SVLFLRDKRWE 133

  Fly   129 TLRQKLTPTFTSGKMK----------------------------------------------TMF 147
            .:|..|...|:..|:.                                              .|.
Human   134 EVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMV 198

  Fly   148 PTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCAFGLDCHSLSDPKAKFVQMGTTA 212
            |.|....|.|:......|.: .|:.:|......:|.||:.|.|||....|...|:..||
Human   199 PLISQACDLLLAHLKRYAES-GDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFV------ 256

  Fly   213 ITERRHGK---------SMDLLLFGAPEL---AAKLRMKATVQEVEDFYMNIIRDTVDYRVKN-- 263
                :|.|         .:.:||...|.:   .|::.......|:..|:..:||:.:..|.:.
Human   257 ----KHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAA 317

  Fly   264 NVKRHDFVDMLIEMK--------LKFD--------NGDKEN------------GLTFNEIAAQAF 300
            ..:|.||:.|:::.:        ..||        .|.|.|            .||.:||..|||
Human   318 EERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAF 382

  Fly   301 IFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMRE-MTYLEKVIDET 364
            ||.:||:|..:.|:.||.|.||.:.|.|:||..|:: |.|:.:...::.|:.| :.||:.||.||
Human   383 IFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLEEGLPYLDMVIAET 446

  Fly   365 MRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQ 429
            :|..|......|.|.|..:....:  |..|..:.:...|:|||||.:|.||.|.||||..:..||
Human   447 LRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ 509

  Fly   430 RPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGI 494
            ....|:||||.|||:|:|:|.|.::|.:.:..::|.|:|:..| :|.|||:..:.. .|..|.|:
Human   510 HRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP-ETQVPLQLESKS-ALGPKNGV 572

  Fly   495 HLKV 498
            ::|:
Human   573 YIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	139/520 (27%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	139/520 (27%)