Protein Alignment Cyp6a20 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 128/544 - (23%)
• Similarity: 236/544 - (43%)
• Gaps: 95/544 - (17%)

  Fly     3 VMIVLLIG---VITFVAWYVHQHFNYWKRRGIPHDEPKIP--YGNTSELMKTVHFADIFKRTYNK 62
            ::::|::|   :...:|| .:..:|..:|.......||..  :|:..          :...|...
Human    20 LLLLLVVGSWLLARILAW-TYAFYNNCRRLQCFPQPPKRNWFWGHLG----------LITPTEEG 73

  Fly    63 LRNKTD-------------GPFVGFYMYFKRMVVVTDIDFAKTV-------------LIREFDKF 101
            |:|.|.             ||.:.|       :|:...|..:::             .||....:
Human    74 LKNSTQMSATYSQGFTVWLGPIIPF-------IVLCHPDTIRSITNASAAIAPKDNLFIRFLKPW 131

  Fly   102 HDRGVFHNERDDPLSANLVNIDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETAS 166
            ...|:.       ||.      |.||...|:.|||.|....:|:.........:.::..:...||
Human   132 LGEGIL-------LSG------GDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLAS 183

  Fly   167 ADSDSMEITNVVARFTADVIGSCAFGLDCHSLSDPK---AKFVQMGTTAITERRHG---KSMDLL 225
            ..|..:::...::..|.|.:..|.|..|.|....|.   |..:::  :|:.|:|..   :.||.|
Human   184 EGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILEL--SALVEKRSQHILQHMDFL 246

  Fly   226 LFGAPELAAKLRMKATVQEVEDFYMNIIRDT--------VD--YRVKNNVKRHDFVDMLIEMKLK 280
            .:.:.:   ..|.....:.|.||...:||:.        :|  ::.|...|..||:|:|:   |.
Human   247 YYLSHD---GRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLL---LS 305

  Fly   281 FDNGDKENGLTFNEIAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGK 345
            .|...|  .|:..:|.|:|..|...|.:|:::.:.:.||.||.|.:.|::.|.|:..:||..:.|
Human   306 KDEDGK--ALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPK 368

  Fly   346 -LDYDSMREMTYLEKVIDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPE 409
             :::|.:.::.:|...:.|::|..|....:.|..||.....:.:. |.||...::..:.:||:|.
Human   369 EIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPT 432

  Fly   410 FYPEPEKFIPERFDEDQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK 474
            .:|:||.:.|.|||.:..:.|....|:||..|||||||..|...::.|.:||::.:|:|....|:
Human   433 VWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE 497

  Fly   475 TVVPLEYRTDDFLLSSKGGIHLKV 498
            ....||     .::.::||:.|:|
Human   498 PRRKLE-----LIMRAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	114/470 (24%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	116/476 (24%)