Protein Alignment Cyp6a20 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 167/529 - (31%)
• Similarity: 261/529 - (49%)
• Gaps: 74/529 - (13%)

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKR---TYNK 62
            |...:::...::....:..|.| ..:|:.|||...| :|:      :.|:.|   :.|   .:::
Human     9 METWVLVATSLVLLYIYGTHSH-KLFKKLGIPGPTP-LPF------LGTILF---YLRGLWNFDR 62

  Fly    63 LRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERD-DP---LSANLVNID 123
            ..|:..|...|.|...:.|:|:.|.|..||||::|.     ..||.|:.. .|   |.:.|...:
Human    63 ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKEC-----YSVFTNQMPLGPMGFLKSALSFAE 122

  Fly   124 GQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGS 188
            .::||.:|..|:|.|||.|.|.|.|.|...||.|:|...:.|. :|.|:.:.:....:|.|||..
Human   123 DEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE-NSKSINLKDFFGAYTMDVITG 186

  Fly   189 CAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLL----------------FGAPELAAKLR 237
            ..||::..||::|:..|:             |:|..||                |..|...| |.
Human   187 TLFGVNLDSLNNPQDPFL-------------KNMKKLLKLDFLDPFLLLISLFPFLTPVFEA-LN 237

  Fly   238 MKATVQEVEDFYMNIIRDTVDYRVKNNVK-RHDFVDMLIEMKLKFDNGDKE----NGLTFNEIAA 297
            :....::|..|..|.|....:.|:|:..| |.||...:|:     ....||    ..|:..|:.|
Human   238 IGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMID-----SQNSKETKSHKALSDLELVA 297

  Fly   298 QAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVID 362
            |:.|...|.::|:|||:.|.:||||.|.|:|.||:.||:.|| .:...:.||::.:|.||:.|::
Human   298 QSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVN 361

  Fly   363 ETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPE-RFDEDQ 426
            ||:|..|||..:.||..:..: .|..: |.||..|:||..|:||||:::.|||||.|| ||.:..
Human   362 ETLRLFPVVSRVTRVCKKDIE-INGVF-IPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKN 424

  Fly   427 VQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK-TVVPLEYRTDDF-LLS 489
            ........::|||.|||||||:||....:.:.:...:.||.|:  |.| |.:||  :.|:. :|.
Human   425 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK--PCKETQIPL--KLDNLPILQ 485

  Fly   490 SKGGIHLKV 498
            .:..|.|||
Human   486 PEKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	150/455 (33%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	151/457 (33%)