DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	500	Identity:	151/500 - (30%)
Similarity:	251/500 - (50%)	Gaps:	68/500 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLIGVITFVAWYVHQHFNY--WKRRGIPHDEPKIPYGNTSELMKTV-HFADIFKRTYNKLRNKT 67
            |||:..:.|  :|::..:::  :|:.|||..:|...:||....:..: .|.|...:.|.|:
Mouse    13 VLLVTSLVF--FYIYGTYSHGLFKKLGIPGPKPLPLFGNIINYLDGMWKFDDDCYKKYGKI---- 71

  Fly    68 DGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERD-DP---LSANLVNIDGQKWK 128
                .|||...:.::.:.|.:..|.||::|.     ..||.|.|. .|   |..::...:.::||
Mouse    72 ----WGFYEGPQPILAIMDPEIIKIVLVKEC-----YSVFTNRRPFGPVGFLKKSITISEDEEWK 127

  Fly   129 TLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCAFGL 193
            .||..|:|||||.|:|.|||.:...||.|:|........: :.:.:.::...::.|||...:.|:
Mouse   128 RLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKE-EPINMKDIFGAYSMDVITGTSCGV 191

  Fly   194 DCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGA---PELAAKLRM-------KATVQEVEDF 248
            :..||::|:..|||    .|.:....|..|..|...   |.|.....|       :.::...:.|
Mouse   192 NIDSLNNPQDPFVQ----KIKKILKFKFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQSMNFFKKF 252

  Fly   249 YMNIIRDTVDYRVKNNVKRHDFVDMLIEMKLKFDNGDKE-NGLTFNEIAAQAFIFFLAGFETSST 312
            ...:.:|.:||..||.|   ||:.::  |..:...|.:. ..|:..|:|||..||...|::.:||
Mouse   253 VKKMKKDRLDYNQKNRV---DFLQLM--MNTQNSKGQESLKALSDLEMAAQTLIFIFGGYDGTST 312

  Fly   313 TMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHLIRV 377
            ::.|.:||||.|.|:|.||:.||:..| .:...:.||::.:|.||:.|::|::|..|||..:.|.
Mouse   313 SISFIMYELATHPDVQKKLQDEIDRAL-PNKAPVTYDALMDMEYLDMVVNESLRLYPVVSRIDRF 376

  Fly   378 ATQHYQHTNPKYNIE-------KGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTF 435
            :         |.::|       |||.|::|...:|.|||::||||.|.||||.::.........:
Mouse   377 S---------KKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIY 432

  Fly   436 LPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLE 480
            :|||:|||||||:||..:.|.:.:..::.||        ||.|.|
Mouse   433 MPFGNGPRNCIGMRFALISVKLAVTGVLQNF--------TVQPCE 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	142/471 (30%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	142/471 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720