DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	498	Identity:	151/498 - (30%)
Similarity:	248/498 - (49%)	Gaps:	39/498 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNT--SELMKTVHFADIFKRTYNKL 63
            ::|...|::.|||.:..|......::.:.|||...| .|:..|  |......:|.....:.|.|:
Zfish     7 LSVTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRP-WPFVGTLLSYAKGLCNFDMECAKKYGKV 70

  Fly    64 RNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIRE-FDKFHDRGVFHNERDDPLSANLVNIDGQKW 127
            ....||..        .:::|.|::..|.||::| :..|.:|.........|.|..::.:..::|
Zfish    71 WGIYDGRL--------PILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERW 127

  Fly   128 KTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDS-MEITNVVARFTADVIGSCAF 191
            |.:|..|:|.||||::|.:||..:|..|..|:   .....|.:. ::|..|||.::.|||.|.:|
Zfish   128 KRMRSTLSPYFTSGRLKEIFPIAMTHADRFIK---NMQKKDPEQPVKIKEVVAPYSLDVITSSSF 189

  Fly   192 GLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKL-RMKATV--QEVEDFYMNII 253
            .:|..|:::|:..|| :......:......:.||:...|.||..| :|..|:  :...||:.:::
Zfish   190 SVDIDSINNPEDPFV-INVKKFIQFNMFNPLLLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVL 253

  Fly   254 RDTVDYRVKNNVKRHDFVDMLIEMKLKFD-------NGDKENGLTFNEIAAQAFIFFLAGFETSS 311
            :...|...|.:..|.||:.::::.::..|       :.....|||.:||.:|:.:|.|.|:||:|
Zfish   254 KKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGGYETTS 318

  Fly   312 TTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLD----YDSMREMTYLEKVIDETMRKRPVVG 372
            ||:.|.||.||.:.|..:||..||:     .|..||    ||::..|.|||..|:|:||..|...
Zfish   319 TTLTFLLYNLATNPDCLEKLVEEID-----KNFPLDTPITYDALMRMDYLEMAINESMRLLPTAP 378

  Fly   373 HLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLP 437
            .|.|.|.:......  ..|.:||.|.:||..:.|||:.:..|.:|.||||..:...:.....|:|
Zfish   379 RLERSAKKTVVING--LTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFIP 441

  Fly   438 FGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLE 480
            ||.|||||||:|:..|.:.:.:..|:.||..| ...:|.:|||
Zfish   442 FGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVE-TCKETQIPLE 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	143/467 (31%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	143/467 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.720