DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	519	Identity:	154/519 - (29%)
Similarity:	258/519 - (49%)	Gaps:	48/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADI-FKRTYNKLR 64
            ::|..:|::.|:|.:..|......::|:.|||...|...:|......|.....|: ..:.|.|:.
Zfish     7 LSVTWILVVLVLTLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLSYTKGFFNFDMECAKKYGKVW 71

  Fly    65 NKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIRE-FDKFHDRGVFHNERDDPLSANLVNIDGQKWK 128
            ...||..        .:::|||::..||::::| :..|.:|...:.:...||:..:..:..::||
Zfish    72 GIYDGRL--------PILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAVKDERWK 128

  Fly   129 TLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDS-MEITNVVARFTADVIGSCAFG 192
            .:|..|:|.||||::|.:||..:|..|..|:   .....|.:. ::|..|:|.::.||:.|.||.
Zfish   129 RIRGTLSPYFTSGRLKEIFPIAMTHADRFIK---NMQKGDHEQPVKIKEVMASYSLDVVTSSAFS 190

  Fly   193 LDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELA---AKLRMKATVQEVEDFYMNIIR 254
            :|..|:::|...||......:.....|..: |||...|.:|   .|:.:....:...||:...:|
Zfish   191 VDIDSINNPDDPFVTNIKNFLKFNLFGLFV-LLLTVFPSIANLLGKMGLSMFSKPTVDFFYKALR 254

  Fly   255 DTVDYRVKNNVK----RHDFVDMLIEMKLKFD------NGDKENGLTFNEIAAQAFIFFLAGFET 309
                 ::|...|    |.||..::|:.::..|      :...|.|||.:||.:|:|||.:.|:||
Zfish   255 -----KIKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTSEQPEKGLTDHEILSQSFIFIMGGYET 314

  Fly   310 SSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLD----YDSMREMTYLEKVIDETMRKRPV 370
            :|||:.|.||.||.:.|..:||..:|:     .|..||    ||::.::.|||..|:|:||..|.
Zfish   315 TSTTLTFLLYNLAINPDCLEKLVEKID-----KNFPLDTPISYDALMKIDYLEMSINESMRLLPT 374

  Fly   371 VGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTF 435
            ...|.||..:..:...  ..|.|.|.:.:||..::.||:.:..|.:|.||||..:...:.....|
Zfish   375 APRLERVCKKTVEMNG--ITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQYAF 437

  Fly   436 LPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGIHLKVT 499
            :|||.|||||||:|:..|.|.:.:..|:.||..| ...:|.:|||...   :...|..|.||:|
Zfish   438 MPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVE-TCKETQIPLELNP---VFQPKVPITLKLT 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	143/483 (30%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	144/485 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910