DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	517	Identity:	156/517 - (30%)
Similarity:	255/517 - (49%)	Gaps:	44/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADI-FKRTYNKLR 64
            ::|...|:..|||.:..|......::|:.|||...|...:|......|.....|: ..:.|.|:.
Zfish     7 LSVTWTLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLSYTKGFFNFDMECAKKYGKVW 71

  Fly    65 NKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIRE-FDKFHDRGVFHNERDDPLSANLVNIDGQKWK 128
            ...||..        .:::|||::..||::::| :..|.:|...:.:...||:..:..:..::||
Zfish    72 GIYDGRL--------PILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWK 128

  Fly   129 TLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDS-MEITNVVARFTADVIGSCAFG 192
            .:|..|:|.||||::|.:||..:|..|..|:   .....|.:. ::|..|||.::.||:.|.:|.
Zfish   129 RIRGTLSPYFTSGRLKEIFPIAMTHADRFIK---NMQKRDHEQPVKIKEVVAPYSLDVVTSSSFS 190

  Fly   193 LDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLF-----GAPELAAKLRMKATVQEVEDFYMNI 252
            :|..|:::|...||   |......:......|:||     ....|..|:.:....:.:.:|:...
Zfish   191 VDIDSINNPDDPFV---TNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMNFFYTA 252

  Fly   253 IRDTVDYRVKNNVKRHDFVDMLIEMKLKFDNG------DKENGLTFNEIAAQAFIFFLAGFETSS 311
            :|...|.. |::..|.||:.::|:.::..|..      ....|||.:||.:|:|||.|.|:||:|
Zfish   253 LRKIKDEH-KDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGGYETTS 316

  Fly   312 TTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLD----YDSMREMTYLEKVIDETMRKRPVVG 372
            ||:.|.|:.||.:.|..:||..||:     .|..||    ||::.:|.|||..|:|:||..|...
Zfish   317 TTLSFLLHNLATNPDCLEKLVEEID-----KNFPLDTPISYDALMKMDYLEMSINESMRLLPTAP 376

  Fly   373 HLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLP 437
            .|.||..:..:...  ..|.|.|.|.:||..::.||:.:..|::|.||||..:...:.....|:|
Zfish   377 RLERVCKKTVELNG--ITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQYAFMP 439

  Fly   438 FGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGIHLKVT 499
            ||.|||||||:||..|.|.:.:..|:.||..| ...:|.:|||...   :...|..|.||:|
Zfish   440 FGLGPRNCIGMRFALMIVKLLVVKLLQNFSLE-TCKETQIPLELTP---VFQPKVPITLKLT 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	144/481 (30%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	145/483 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720