DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a20 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	167/521 - (32%)
Similarity:	291/521 - (55%)	Gaps:	33/521 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPK-IPYGNTSELM---KTVHFA--DIFKRT 59
            |..:|:|.:.::|...:|:.:|:.||:|||.|.::.. ||:|....:.   |::..|  |::.::
  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDVYVKS 65

  Fly    60 YNKLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDPLSANLVNIDG 124
            ..::        :|.|:.|:..|::.|.|.|:.||.::|..||||||:.:|..||||||:.::.|
  Fly    66 KERV--------LGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRG 122

  Fly   125 QKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELI-RVFGETASADSDSMEITNVVARFTADVIGS 188
            |.|:::|..|:|.|||||:|:||.|...:||::: .:..|........::|..|:..:..|:|.|
  Fly   123 QSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAS 187

  Fly   189 CAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKLRMKATVQEVEDFYMNII 253
            ..||||.:|..:|..||.::.:.|....|......:::|..|.:|..|........|....:.|:
  Fly   188 TIFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIV 252

  Fly   254 RDTVDYRVKNNVKRHDFVDMLIEMKL--KFDNGDKEN------------GLTFNEIAAQAFIFFL 304
            ::||:||.|:.:.|.|.:.:||:::.  |.|..|:::            .::...|.||||||::
  Fly   253 KETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYI 317

  Fly   305 AGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRP 369
            ||.||:.:|..|.:||||.:.::..:|:.|::..|.:::||:.|||:.:|.:|:..:.||:||.|
  Fly   318 AGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYP 382

  Fly   370 VVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACT 434
            .:..|.|..||.|...:..:.|.|||.|::....||||.|::|:||.:.||||.|:.....|. .
  Fly   383 GLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESRNYNPT-A 446

  Fly   435 FLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGIHLKVT 499
            |:|||:|||.||..|.||:...:.:..::.||..|......:   |:......|..|.|:.::::
  Fly   447 FMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI---EFENSGIALIPKHGVRVRLS 508

  Fly   500 R 500
            :
  Fly   509 K 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	156/484 (32%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	148/453 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970