Protein Alignment Cyp6a20 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 136/538 - (25%)
• Similarity: 239/538 - (44%)
• Gaps: 84/538 - (15%)

  Fly     4 MIVLLIG----VITFVAWYVHQHFNYWKRRGIPHDEPK---------IPYGNTSELMKTVHFADI 55
            :::||:|    :...:||....:.|..:.|..| ..||         :.:.:...|:.|...|
Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFP-QPPKRNWFLGHLGLIHSSEEGLLYTQSLA-- 81

  Fly    56 FKRTYNKLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDPLSANLV 120
              .|:..:.....||:......| ....:..:.||...::.: ||     ||::.....|...|:
Human    82 --CTFGDMCCWWVGPWHAIVRIF-HPTYIKPVLFAPAAIVPK-DK-----VFYSFLKPWLGDGLL 137

  Fly   121 NIDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGET-----------ASADSDSMEI 174
            ...|:||...|:.|||.|....:|           ..:::|.|:           ||..|..:::
Human   138 LSAGEKWSRHRRMLTPAFHFNILK-----------PYMKIFNESVNIMHAKWQLLASEGSARLDM 191

  Fly   175 TNVVARFTADVIGSCAFGLDCHSLSDPK---AKFVQMGTTAITERRHGKSM---DLLLFGAPELA 233
            ...::..|.|.:..|.|..|.|....|.   |..:::  :|:..:||.:.:   |.|.:..|:
Human   192 FEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILEL--SALVTKRHQQILLYIDFLYYLTPD-- 252

  Fly   234 AKLRMKATVQEVEDFYMNIIRDT--------VD--YRVKNNVKRHDFVDMLIEMKLKFDNGDKEN 288
             ..|.:...:.|.||...:|::.        ||  .:.|...|..||:|:|:   |..|...|:
Human   253 -GQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLL---LSKDEDGKK- 312

  Fly   289 GLTFNEIAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGK-LDYDSMR 352
             |:..:|.|:|..|...|.:|:::.:.:.||.||.|.:.|::.|.|:..:||....| :::|.:.
Human   313 -LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376

  Fly   353 EMTYLEKVIDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKF 417
            ::.:|...|.|::|..|.|..:.|..||.....:.:. |.||...::.....||:|..:|:||.:
Human   377 QLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVY 440

  Fly   418 IPERFDEDQVQQRPACTFLPFGDGPRNCIGLRF--GRMQVIVGMALLIHNFKFEFHPTKTVVPLE 480
            .|.|||...:::|....|:||..|||||||..|  ..|:|::|:.||    :|...|..|.   .
Human   441 DPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL----RFRVLPDHTE---P 498

  Fly   481 YRTDDFLLSSKGGIHLKV 498
            .|..:.:|.::||:.|:|
Human   499 RRKPELVLRAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	120/457 (26%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	124/480 (26%)