DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	172/540 - (31%)
Similarity:	278/540 - (51%)	Gaps:	70/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMK-TVHFADIFKRTYNKLR 64
            :.:::..||| |.|:|  :.||::||:|.|:....||...||...|:. .:..|:...:.||. .
  Fly     5 LLILVASLIG-IAFLA--LQQHYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAEFISQLYNH-P 65

  Fly    65 NKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDPL-SANLVNIDGQKWK 128
            :..:.||||.:::.|..:::.|.:..:.:|:::|..|.:|....:.:.||| |.|:..:....||
  Fly    66 DAENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIFFLKNPAWK 130

  Fly   129 TLRQKLTPTFTSGKMKTMFPTILTVG-------------DELIRVFGETASADSDSMEITNVVAR 180
            .:|.||:|.||..::|.|||.|..||             :|.:|.|         .:|...:.|.
  Fly   131 EVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCF---------DLEAKELCAL 186

  Fly   181 FTADVIGSCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSM----------DLLLFGAPELAAK 235
            :|.|||.:.|:|:..:|.:|||.:|          ||||:|:          ..|:|..|.|...
  Fly   187 YTTDVIATVAYGVSANSFTDPKCEF----------RRHGRSVFEFNLLRAAEFTLVFFLPHLVPF 241

  Fly   236 LRMKATVQEVEDFYMNIIRDTVDY----RVKNNVKRHDFVDMLIEMK----LKFDNGDKENGLTF 292
            :|.|....|...|    :|.|::|    |.|:..||:|.:|:|||.:    |...:|.|:..:..
  Fly   242 VRFKVVPAEATRF----LRKTINYVMSEREKSGQKRNDLIDILIEFRRSTQLAKASGIKDQFVFE 302

  Fly   293 NEI-AAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTY 356
            .:| .|||.:||.||||:||:||.||:||||...|:|.:||.||...|.:..|::....:..:.:
  Fly   303 GDILVAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEF 367

  Fly   357 LEKVIDETMRKRPVVGHLIRVATQHYQHT----NPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKF 417
            ::.::.|.:|..|.:..|.|..|....::    :.|:.:.||..|.:|..|:|.||:::|:|.||
  Fly   368 MQMILLEVLRMYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKF 432

  Fly   418 IPERFDEDQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYR 482
            :||||..:..:.....|::|||.||..|||.|||.:|..||:..|:.|...   .|....|...:
  Fly   433 LPERFSPENRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMI---TTSERTPHRMQ 494

  Fly   483 TDD--FLLSSKGGIHLKVTR 500
            .|.  .:..:||||||::.|
  Fly   495 LDPKAIITQAKGGIHLRLVR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	157/503 (31%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	158/501 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970