Protein Alignment Cyp6a20 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 542
• Identity: 122/542 - (22%)
• Similarity: 228/542 - (42%)
• Gaps: 133/542 - (24%)

  Fly     6 VLLIGVITFVAW-----YVHQ-------------------HFNY-WKRRGIPHDEPKIPYGNTSE 45
            :||:|....:|:     :||:                   |..| ||:     ||.      ...
  Rat     5 LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKK-----DEA------CGR 58

  Fly    46 LMKTVHFADIFKRTYNKLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNE 110
            :::.| |.|..|:.         ||.|...::.|..|:||..:..|..|:.  .|::
  Rat    59 VLQDV-FLDWAKKY---------GPVVRVNVFHKTSVIVTSPESVKKFLMS--TKYN-------- 103

  Fly   111 RDDPLSANLVNIDGQ--------------KWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVF 161
            :|..:...:..:.|:              :|...|:.:...|:...:.::..|.....::|:.:.
  Rat   104 KDSKMYRAIQTVFGERLFGQGLVSECDYGRWYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEIL 168

  Fly   162 GETASADSDS-MEITNVVARFTADVIGSCAFGLDCHSL---SDPKAKFVQMGTTAITERRHGKSM 222
              .|.||..: :.:.:::...|.|::...|||::...|   ..|.::.|::....|:..|:
  Rat   169 --EAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRN---- 227

  Fly   223 DLLLFGAPELAAKLRMKATVQEVEDFYMNIIRDTVDYRVKNNVKRHDFV--DMLIEMKLKFDNGD 285
            .|..|    :..|.:....::|.......:.:|.|..| :..:||.:.|  |:|.:: ||.:.|.
  Rat   228 TLAKF----MPGKRKQLREIRESIRLLRQVGKDWVQRR-REALKRGEDVPADILTQI-LKAEEGA 286

  Fly   286 KENGLTFNEIAAQAFI-FFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVL--KQHNGKLD 347
            ::     :|:....|: ||:||.|||:..:.|.:.||:...:|..:|:.|::.|:  |:|   ||
  Rat   287 QD-----DEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH---LD 343

  Fly   348 YDSMREMTYLEKVIDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGT---GVIVP--------T 401
            |:.:..:.||.:|:.|::|..|......|:             :|:.|   ||.||        |
  Rat   344 YEDLGRLQYLSQVLKESLRLYPPAWGTFRL-------------LEEETLIDGVRVPGNTPLLFST 395

  Fly   402 LAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNF 466
            ..:.....::.:|..|.|:||...  ..:|..|:.||..|.|:|||.:|.:|:|.|.||.|:...
  Rat   396 YVMGRMDTYFEDPLTFNPDRFGPG--APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458

  Fly   467 KFEFHPTK--------TVVPLE 480
            :|...|.:        |:.||:
  Rat   459 EFRLVPGQRFGLQEQATLKPLD 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	106/456 (23%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	110/475 (23%)