DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	147/493 - (29%)
Similarity:	245/493 - (49%)	Gaps:	42/493 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGN-TSELMKTVHFADIFKRTYNKLRNKT 67
            :::..||::.| .|.... |..::.|.:..::|....|| .:..::...|.......||:.|:.
  Fly     8 LVLATIGLLLF-KWSTGT-FKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRHH- 69

  Fly    68 DGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKF--HDRGVFHNERDDPLSANLVNI-DGQKWKT 129
              ..||.:.....|:.:.|....|.:.:::||.|  |......|||   |..:::|: ..|.|:.
  Fly    70 --KLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPNER---LVNDMLNVMRDQHWRN 129

  Fly   130 LRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGE--------TASADSDSMEITNVVARFTADVI 186
            :|..|||.|||.||:.||    |:.:|......|        .|..::..:::..:..:.:.|||
  Fly   130 MRSVLTPVFTSAKMRNMF----TLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVI 190

  Fly   187 GSCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKL--RMKATVQEVE--D 247
            .:.||||..:|..||:.:|..:|.|....|    .:..|.|....||.|:  ..|.|:.:..  :
  Fly   191 ATTAFGLKVNSFDDPENEFHTIGKTLAFSR----GLPFLKFMMCLLAPKVFNFFKLTIFDSTNVE 251

  Fly   248 FYMNIIRDTVDYRVKNNVKRHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFETSST 312
            :::.::.|.:.||.|:|:.|.|.:.:|:|.|.:    .|:| .|.:||.||.||||.|.||.:|.
  Fly   252 YFVRLVVDAMQYREKHNITRPDMIQLLMEAKKE----SKDN-WTDDEIVAQCFIFFFAAFENNSN 311

  Fly   313 TMGFALYELACHQDIQDKLRTEINTVLKQHNG-KLDYDSMREMTYLEKVIDETMRKRPVVGHLIR 376
            .:....|||..:.|||::|..|:....:...| .|.||:.:||||::.||.|::||..:.....|
  Fly   312 LICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAADR 376

  Fly   377 VATQHYQHTNPK----YNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLP 437
            :..:.|..|:.:    :..:.|..:.:|...:|.|..|:|:|::|.||||.|.:.:.....|:||
  Fly   377 LCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYTYLP 441

  Fly   438 FGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKT 475
            ||.|||:|||.|:..||....:..|:.|:|.|..|..|
  Fly   442 FGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTT 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	141/465 (30%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	140/459 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.870