DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	516	Identity:	170/516 - (32%)
Similarity:	272/516 - (52%)	Gaps:	55/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTV--HFADIFK---RTYNKLR 64
            :|||..::..:..|..:....:|::|||..:| :|:      :.||  ::..|:|   ..|.|.
Mouse    12 LVLLAIILVLLYRYGTRTHGLFKKQGIPGPKP-LPF------LGTVLNYYTGIWKFDMECYEKY- 68

  Fly    65 NKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERD-DP--LSANLVNID-GQ 125
            .||.|.|.|    ...::|:||.:..|.||:::.     ..||.|.|: .|  :.:..::|. .:
Mouse    69 GKTWGLFDG----QTPLLVITDPETIKNVLVKDC-----LSVFTNRREFGPVGIMSKAISISKDE 124

  Fly   126 KWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCA 190
            :||..|..|:||||||::|.|||.|...||.|::...:.|.... .:.:.:|:..::.|||.|.:
Mouse   125 EWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGM-PVAMKDVLGAYSMDVITSTS 188

  Fly   191 FGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDL---LLFGA---PELAAKLRMKATVQEVED-- 247
            ||::..||::|:..||:       |.:....:|.   |||..   |.|.....|........|
Mouse   189 FGVNVDSLNNPEDPFVE-------EAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSI 246

  Fly   248 -FYMNIIRDTVDYRVKNNVK-RHDFVDMLIEMKLKFDNGDKENGLTFN--EIAAQAFIFFLAGFE 308
             |:...:....:.|:.:|.| |.||:.::  |....::.||::...|:  ||..|:.||..||:|
Mouse   247 EFFKKFVDRMQESRLDSNQKHRVDFLQLM--MNSHNNSKDKDSHKAFSNMEITVQSIIFISAGYE 309

  Fly   309 TSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGH 373
            |:|:|:.|.||.||.|.|||.||:.||:..| .:......|::.||.||:.|::||:|..|:|..
Mouse   310 TTSSTLSFTLYCLATHPDIQKKLQAEIDKAL-PNKATPTCDTVMEMEYLDMVLNETLRLYPIVTR 373

  Fly   374 LIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLPF 438
            |.||..:..: .|..| |.||:.|::|:.|:||||:.:|:||:|.||||.::.........:|||
Mouse   374 LERVCKKDVE-LNGVY-IPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPF 436

  Fly   439 GDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHP-TKTVVPLEYRTDDFLLSSKGGIHLKV 498
            |.|||||||:||..|.:.:.:..::.||.|:  | .:|.:||:......|...| .|.|||
Mouse   437 GIGPRNCIGMRFALMNMKLAVTKVLQNFSFQ--PCQETQIPLKLSRQGILQPEK-PIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	160/485 (33%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	161/487 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720