DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	134/525 - (25%)
Similarity:	238/525 - (45%)	Gaps:	69/525 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKRTYNKLRN-- 65
            |:..:|..:..|:.|    :|:|||:||||             ..|:..|...|...:.:.||
  Fly    10 VIAAILALIYVFLTW----NFSYWKKRGIP-------------TAKSWPFVGSFPSVFTQKRNVV 57

  Fly    66 ----------KTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGV--FHNERDDPLSAN 118
                      |.....||.:......::||..::|..:.:.:|..|||..:  |.:.:.||:.||
  Fly    58 YDIDEIYEQYKNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILAN 122

  Fly   119 LVN---IDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIR-VFGETASADSDSMEITNVVA 179
              |   :.|:.||..|.::||..::.::|..:|..|.|..:.:. :..::..|.:..:...::..
  Fly   123 --NPFVLTGEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCL 185

  Fly   180 RFTADVIGSCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGA-----PELAAKLRMK 239
            .:|.:||..|..|:...|.:|.....|.|     |:|...:|...:.:..     |.:.....:.
  Fly   186 CYTTEVISDCVLGISAQSFTDNPTPMVGM-----TKRVFEQSFGFIFYTVVANLWPPITKFYSVS 245

  Fly   240 ATVQEVEDFYMNIIRDTVDYRVKNNV--KRHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIF 302
            ...::|..|:.::::..:..|.::..  :|.||::.:::::       ::.||...|:.:....|
  Fly   246 LFAKDVAAFFYDLMQKCIQVRRESPAAQQRDDFLNYMLQLQ-------EKKGLNAAELTSHTMTF 303

  Fly   303 FLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRK 367
            ...||||::..:...|..||.:...|.|||.||.|      .:|.::.:.|:.:.|..|.||:|.
  Fly   304 LTDGFETTAQVLTHTLLFLARNPKEQMKLREEIGT------AELTFEQISELPFTEACIHETLRI 362

  Fly   368 RPVVGHLIRVATQHYQHTNP---KYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERF---DEDQ 426
            ...|....:|.|:..:.||.   ...:..|..||:|..|:||||::|.||:.|.||||   :...
  Fly   363 FSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGA 427

  Fly   427 VQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSK 491
            .:.|....|..||||||.|.|:||...|:...:..::.||..:.:| ||....|.....|:.:.|
  Fly   428 KKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNP-KTRKDNEIDDTYFMPALK 491

  Fly   492 GGIHL 496
            ||:.|
  Fly   492 GGVWL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	122/494 (25%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	117/475 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.970