DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and Cyp309a2

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	117/482 - (24%)
Similarity:	230/482 - (47%)	Gaps:	31/482 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELM--KTVHFADIFKRTYNKL 63
            :.::.:|::.:..::.|    |..||::||:....|....|....|:  |:....|: ::.|:|.
  Fly    40 LILLHLLVLPIYLYLTW----HHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDV-QKIYDKY 99

  Fly    64 RNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREF----DKFHDRGVFHNERDDPLSANLVNIDG 124
            :.|...  ||.::..:..::|.|.:.|..||:..|    |......:.|.:.|.....|.....|
  Fly   100 KGKHRA--VGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWASG 162

  Fly   125 QKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSC 189
            |.|:.||.......:..:::..:......|..|.....:..:..::.:|..::..|:||.|:...
  Fly   163 QSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMADF 227

  Fly   190 AFGLDCHSLSDPKA---KFVQMGTTAITERRHGKSMDLLLFGAPELAAKLRMKATVQEVEDFYMN 251
            .:|:|..:|:.|..   |..:|.:...:...:..::.:....||.....||.:...:|.::|:.|
  Fly   228 IWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFSN 292

  Fly   252 IIRDTVDYRVK-NNVKRHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFETSSTTMG 315
            :.:::::.|:| .:..|.|::..|::::      |::.. |.:::...|....|.|::||.|.:.
  Fly   293 LTKESIELRLKAGDSTRTDYLSHLLQLR------DQKQA-THDDLVGHALTVMLDGYDTSGTALL 350

  Fly   316 FALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHLIRVATQ 380
            .|||.||.:..:|.|||.||.:.:.... .||::.:..:.|||:||.|::|...::....:|.|.
  Fly   351 HALYYLAENPAVQQKLRVEILSCMASEK-SLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTL 414

  Fly   381 H---YQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQ--RPACTFLPFGD 440
            .   ....:...::|.|..:::|....|||.:::||||.|.|||||....|:  |.. .||||.|
  Fly   415 PTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRKG-IFLPFSD 478

  Fly   441 GPRNCIGLRFGRMQVIVGMALLIHNFK 467
            |||.|:|:....:.:...:..::.||:
  Fly   479 GPRICMGVPLAMLTLKSALVHILSNFQ 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	110/451 (24%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	110/448 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.970