Protein Alignment Cyp6a20 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 118/448 - (26%)
• Similarity: 210/448 - (46%)
• Gaps: 41/448 - (9%)

  Fly    69 GPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDP--LSANLVNIDGQKWKTLR 131
            |||..|:..:       |.|:|||:|.|...|..     :.::..|  |...|..:||.||...|
Human    85 GPFQAFFCIY-------DPDYAKTLLSRTDPKSQ-----YLQKFSPPLLGKGLAALDGPKWFQHR 137

  Fly   132 QKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCAFG--LD 194
            :.|||.|....:|.....:......::..:.:..|....|:|:...:...:.|:|..|||.  .:
Human   138 RLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN 202

  Fly   195 C--HSLSDPKAKFVQMGTTAITERRHG--KSMDLLLFGAPELAAKLRMKATVQEVEDFYMNIIRD 255
            |  :|..||.||.:...:..|..|.:.  ...|::...:|:.....::...:.:..|..:...:.
Human   203 CQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 267

  Fly   256 TVDYRVK--NNVKR--HDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFI--FFLAGFETSSTTM 314
            ::...||  |..||  .||:|:::..|       .|:|.:|::|...:.:  |.|||.:|.:.::
Human   268 SLQAGVKQDNTPKRKYQDFLDIVLSAK-------DESGSSFSDIDVHSEVSTFLLAGHDTLAASI 325

  Fly   315 GFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHLIRVAT 379
            .:.||.||.:.:.|::.|.|:..:|.. ...:.:|.:.||:|....|.||.|..|.|..:.|..:
Human   326 SWILYCLALNPEHQERCREEVRGILGD-GSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389

  Fly   380 QHYQHTNPK-YNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLPFGDGPR 443
            :..  |.|. ..:..|..|::....:||:|..:..|:.|.|.||.::...||....:|||..|.|
Human   390 KPL--TFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSR 452

  Fly   444 NCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGIHLKVTRV 501
            ||||..|..:::.|.:||::.:|:....||:   ||.: .:.|:|..|.|::|.:.::
Human   453 NCIGQEFAMIELKVTIALILLHFRVTPDPTR---PLTF-PNHFILKPKNGMYLHLKKL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	117/440 (27%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	117/442 (26%)
		heme binding region	447..460		7/12 (58%)