DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and cyp-13A10

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_496085.3	Gene:	cyp-13A10 / 174522	WormBaseID:	WBGene00014254	Length:	519	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	143/541 - (26%)
Similarity:	251/541 - (46%)	Gaps:	103/541 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIV----LLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKRTYN 61
            |:|:::    |.||.|::..|.    :.||:|||||........|:..:.:|:.:...:..|.:.
Worm     1 MSVILLAIPTLFIGFISYYLWI----WTYWRRRGIPGPLGYPLVGSFPKTLKSEYPQYLQIRDWT 61

  Fly    62 KLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHN------ERDDPLSANLV 120
            ||.    ||..|:.....:.::|:|||..:.:.:.::|.|:.|.:  |      |:|:  ..||.
Worm    62 KLY----GPIYGYTEGTIKTLIVSDIDIVRQIFVEQYDNFYGRKL--NPIQGDPEKDE--RTNLF 118

  Fly   121 NIDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADV 185
            :..|.:||.||...:|||::..::.:..|:.....||:|...|..| :...:::......||.|.
Worm   119 SAQGFRWKRLRAISSPTFSNNSLRKINVTVEDSAMELLRHIEEQTS-EGQQIDMLQFYQEFTMDT 182

  Fly   186 IGSCAFG-LDCHSLSDPKAKFVQMGTTAI--TERRHGKSMDLLLFGA--PELAAKLRM------- 238
            ||..|.| .|.....:|..|||:    ||  ..|:|     :.|.|.  |.||...|.
Worm   183 IGRIAMGQTDSQMFKNPLLKFVR----AIFGDNRKH-----IPLIGGVFPTLAQVFRFFMLKFPL 238

  Fly   239 --KATVQEVEDFYMNIIRDTVDYRV---KNNV---KRHDFVDMLIEMK------LKFDNGD---- 285
              .|....|....:..:::.:|.|.   ||.:   :..||:|:.:|.:      .:.:|||
Worm   239 LGAANFIHVNKTVVTAVQNRIDQRENDRKNGIEIGEPQDFIDLFLEARADDVEHFQENNGDFSKT 303

  Fly   286 ---KENGLTFNEIAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLD 347
               ....||..||..|..:|.:|||:|::.::.:..:.||.|.::|.||:.||.....:.:  :.
Worm   304 SSYGNRQLTTQEIVGQCLVFLIAGFDTTALSLSYTTFLLATHPEVQKKLQEEIERECIEPS--IS 366

  Fly   348 YDSMREMTYLEKVIDETMRKRPV--------------VGHLIRVATQHYQHTNPKYNIEKGTGVI 398
            :|.:.::.|::.:|.||:|..|:              :|::               .:|.||.|.
Worm   367 FDHLSKLKYMDCIIKETLRLYPLGTMANSRRCMRATKLGNV---------------EVEVGTMVQ 416

  Fly   399 VPTLAIHHDPEFYPEPEK-FIPERFDE---DQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGM 459
            |.|.::|.|.:.:.:..| |.|||:.:   |||.|:..  ::.||.|||.|:|:|...|:..:.:
Worm   417 VDTWSLHTDTKIWGDDAKEFKPERWLDPNCDQVFQKGG--YISFGLGPRQCVGMRLAYMEEKMLL 479

  Fly   460 ALLIHNFKFEFHPTKTVVPLE 480
            |.::..:.||. .|||.:||:
Worm   480 AHILRKYTFEV-GTKTEIPLK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	130/506 (26%)
cyp-13A10	NP_496085.3	p450	32..500	CDD:278495	130/506 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28638
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm4759
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.730