DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	179/530 - (33%)
Similarity:	272/530 - (51%)	Gaps:	78/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAWYVH---QHFNYWKRRGIPHDEPKIPY-GNTSELMKTVH-FADIFKRTY 60
            :|.::|||         |::   .|.|: |:.||...:| :|: ||   ::...| |.:..:..:
  Rat    15 LATILVLL---------YLYGTSTHGNF-KKLGISGPKP-LPFVGN---ILAYRHGFWEFDRHCH 65

  Fly    61 NKLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIRE-FDKFHDRGVFHNERDDP---LSANLVN 121
            .|.     |...|||...:.::.:||.|..||||::| :..|.:|..|     .|   |...:..
  Rat    66 KKY-----GDIWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSF-----GPAGILKKAITL 120

  Fly   122 IDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIR-VFGETASADSDSMEITNVVARFTADV 185
            .:.::||.||..|:|||||||:|.|||.|....|.|:: |..|....:..:|:  ::...::.||
  Rat   121 SEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMK--DIFGAYSMDV 183

  Fly   186 IGSCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFG---------------APELAAK 235
            |...:||::..||::|:..|||            |...||.|.               .|...|
  Rat   184 ITGTSFGVNVDSLNNPQNPFVQ------------KVKKLLKFNFLDPFFLSVILFPFLTPVFEA- 235

  Fly   236 LRMKATV--QEVEDFYMNIIRDTVDYRVKNNVK-RHDFVDMLIEMKLKFDNGDKEN--GLTFNEI 295
              ...||  ::|..|:...:....:.|::..|| |.||:.::|..:   .:||||:  |||..||
  Rat   236 --FDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMINSQ---SSGDKESHQGLTDVEI 295

  Fly   296 AAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKV 360
            .||:..|..||:||:|:.:.||||.||.|.|:|.||:.||:..| .:...:.||.:.||.||:.|
  Rat   296 VAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL-PNKAPVTYDVLVEMEYLDMV 359

  Fly   361 IDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDED 425
            ::||:|..||.|.|.||..:..: .|..: |.|||.|:|||.|:|.||:.:||||:|.||||.:.
  Rat   360 LNETLRLFPVGGRLERVCKKDVE-INGVF-IPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKK 422

  Fly   426 QVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSS 490
            .........:||||:|||||||:||..|.:.:.:..::.||.|.. ..:|.:||:.|...|....
  Rat   423 NQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGL-CKETQIPLKLRKKGFFQPE 486

  Fly   491 KGGIHLKVTR 500
            |..|...|:|
  Rat   487 KPIILRAVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	167/490 (34%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	166/489 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770