Protein Alignment Cyp6a20 and CYP4B1

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 125/542 - (23%)
• Similarity: 222/542 - (40%)
• Gaps: 110/542 - (20%)

  Fly     5 IVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIP-------YGN------TSELMKTVHFADIF 56
            ::|::|.:..:...:       :|:.:.....|.|       :|:      |..|.|.|.:|..|
Human    20 LILVLGFLKLIHLLL-------RRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQF 77

  Fly    57 KRTYNKLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDP------- 114
            ...:    ....|.|:||       :.:.:.|:||.|        :.||       ||
Human    78 PYAH----PLWFGQFIGF-------LNIYEPDYAKAV--------YSRG-------DPKAPDVYD 116

  Fly   115 -----LSANLVNIDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEI 174
                 :...|:.::|.||...|:.|||.|....:|. :..:.|....::....|..:.:..|.:|
Human   117 FFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKP-YVAVFTESTRIMLDKWEEKAREGKSFDI 180

  Fly   175 TNVVARFTADVIGSCAFGLDCHSLSDPKAKFVQMGTTAIT---ERR------HGKSMDLLLFGAP 230
            ...|.....:.:..|.||.....|...:.....:..:.:|   ::|      |.   |.:.:..|
Human   181 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN---DFIYWLTP 242

  Fly   231 ELAAKLRMKATVQEVEDFYMNIIRD----TVDYRVKNNV--KRH-DFVDMLI----EMKLKFDNG 284
            .....||   ..|...|....:||:    ..|.:|:..:  :|| ||:|:|:    |..:|..:.
Human   243 HGRRFLR---ACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDA 304

  Fly   285 DKENGLTFNEIAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDY- 348
            |         :.|:...|...|.:|:::.:.:.||.:|.:.:.|.:.|.|:..:|    |..|:
Human   305 D---------LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL----GDQDFF 356

  Fly   349 --DSMREMTYLEKVIDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFY 411
              |.:.:||||...|.|:.|..|.|..:.|..::.....:.: ::..|:.:.:...|:|.:...:
Human   357 QWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVW 420

  Fly   412 PEPEKFIPERFDEDQVQQRPACTFLPFGDGPRNCIGLRF--GRMQVIVGMALLIHNFKFEFHPTK 474
            |:||.|...||..:...:|....|:||..|||||||.:|  ..|:|:..|.||  .|:|...|::
Human   421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL--RFEFSLDPSR 483

  Fly   475 TVVPLEYRTDDFLLSSKGGIHL 496
                |..:....:|.||.|.||
Human   484 ----LPIKMPQLVLRSKNGFHL 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	111/464 (24%)
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	118/488 (24%)