Protein Alignment Cyp6a20 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 164/519 - (31%)
• Similarity: 268/519 - (51%)
• Gaps: 55/519 - (10%)

  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPY-GNTSELMKTVHFADI-FKRTYNKL 63
            |...::|.:.::....:..|.| ..:|:.|||...| :|: ||.....|.....|: ..:.|.|:
Human     9 METWLLLAVSLVLLYLYGTHSH-GLFKKLGIPGPTP-LPFLGNILSYHKGFCMFDMECHKKYGKV 71

  Fly    64 RNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERD-DPLS--ANLVNI-DG 124
                    .|||...:.::.:||.|..||||::|.     ..||.|.|. .|:.  .:.::| :.
Human    72 --------WGFYDGQQPVLAITDPDMIKTVLVKEC-----YSVFTNRRPFGPVGFMKSAISIAED 123

  Fly   125 QKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSC 189
            ::||.||..|:|||||||:|.|.|.|...||.|:|.....|.. ...:.:.:|...::.|||.|.
Human   124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET-GKPVTLKDVFGAYSMDVITST 187

  Fly   190 AFGLDCHSLSDPKAKFVQMGTTAITERRHGK-------------SMDLLLFGAPELAAKLRMKAT 241
            :||::..||::|:..||:          :.|             |:.:..|..|.|.. |.:...
Human   188 SFGVNIDSLNNPQDPFVE----------NTKKLLRFDFLDPFFLSITVFPFLIPILEV-LNICVF 241

  Fly   242 VQEVEDFYMNIIRDTVDYRVKNNVK-RHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLA 305
            .:||.:|....::...:.|:::..| |.||:.::|:.:...:. :....|:..|:.||:.||..|
Human   242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKET-ESHKALSDLELVAQSIIFIFA 305

  Fly   306 GFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPV 370
            |:||:|:.:.|.:||||.|.|:|.||:.||:.|| .:.....||::.:|.||:.|::||:|..|:
Human   306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPI 369

  Fly   371 VGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTF 435
            ...|.||..:..: .|..: |.||..|::|:.|:|.||:::.|||||:||||.:..........:
Human   370 AMRLERVCKKDVE-INGMF-IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIY 432

  Fly   436 LPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK-TVVPLEYRTDDFLLSSKGGIHLKV 498
            .|||.|||||||:||..|.:.:.:..::.||.|:  |.| |.:||:..... ||..:..:.|||
Human   433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK--PCKETQIPLKLSLGG-LLQPEKPVVLKV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	154/484 (32%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	155/486 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820