Protein Alignment Cyp6a20 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_611002.3
• Gene: Cyp6a20 / 36664
• FlyBaseID: FBgn0033980
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 113/457 - (24%)
• Similarity: 201/457 - (43%)
• Gaps: 87/457 - (19%)

  Fly    66 KTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDPLSANLVNIDG------ 124
            |..||.|...::.|..|:||..:..|..|:.  .|::        :|..:...|..:.|
Human    69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMS--TKYN--------KDSKMYRALQTVFGERLFGQ 123

  Fly   125 --------QKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARF 181
                    ::|...|:.:...|:...:.::..|.....::|:.:.  .|.||..:......:..:
Human   124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEIL--EAKADGQTPVSMQDMLTY 186

  Fly   182 TA-DVIGSCAFGLDCHSL---SDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKLRMKATV 242
            || |::...|||::...|   ..|.::.|::....||..|:    .|..|    |..|.:....|
Human   187 TAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRN----TLAKF----LPGKRKQLREV 243

  Fly   243 QEVEDFYMNIIRDTVDYRVKNNVKRHDFV--DMLIEMKLKFDNGDKEN-GLTFNEIAAQAFIFFL 304
            :|...|...:.||.|..| :..:||.:.|  |:|.:: ||.:.|.::: ||..|.:.     ||:
Human   244 RESIRFLRQVGRDWVQRR-REALKRGEEVPADILTQI-LKAEEGAQDDEGLLDNFVT-----FFI 301

  Fly   305 AGFETSSTTMGFALYELACHQDIQDKLRTEINTVL--KQHNGKLDYDSMREMTYLEKVIDETMRK 367
            ||.|||:..:.|.:.||:...:|..:|:.|::.|:  |::   ||::.:..:.||.:|:.|::|.
Human   302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY---LDFEDLGRLQYLSQVLKESLRL 363

  Fly   368 RPVVGHLIRVATQHYQHTNPKYNIEKGT---GVIVP--------TLAIHHDPEFYPEPEKFIPER 421
            .|......|:             :|:.|   ||.||        |..:.....::.:|..|.|:|
Human   364 YPPAWGTFRL-------------LEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415

  Fly   422 FDEDQVQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK--------TVVP 478
            |...  ..:|..|:.||..|.|:|||.:|.:|:|.|.||.|:...:|...|.:        |:.|
Human   416 FGPG--APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKP 478

  Fly   479 LE 480
            |:
Human   479 LD 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	CYP6-like	67..495	CDD:410679	112/456 (25%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	113/457 (25%)