DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and CYP3A7-CYP3A51P

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001243426.2	Gene:	CYP3A7-CYP3A51P / 100861540	HGNCID:	51504	Length:	535	Species:	Homo sapiens

Alignment Length:	505	Identity:	167/505 - (33%)
Similarity:	265/505 - (52%)	Gaps:	38/505 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVMIVLLIGVITFVAW-YVHQHFNYWKRRGIPHDEPKIPY-GNTSELMKTVHFADIFKRTYNKL 63
            :||...||:.|...:.: |..:....:|:.|||...| :|: ||.....|.....|:  ..|.|.
Human     7 LAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTP-LPFLGNALSFRKGYWTFDM--ECYKKY 68

  Fly    64 RNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERD-DPLS--ANLVNI-DG 124
            |.     ..|.|...:.|:.:||.|..||||::|.     ..||.|.|. .|:.  .|.::| :.
Human    69 RK-----VWGIYDCQQPMLAITDPDMIKTVLVKEC-----YSVFTNRRPFGPVGFMKNAISIAED 123

  Fly   125 QKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSC 189
            ::||.:|..|:|||||||:|.|.|.|...||.|:|.....|.. ...:.:.:|...::.|||.|.
Human   124 EEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET-GKPVTLKHVFGAYSMDVITST 187

  Fly   190 AFGLDCHSLSDPKAKFVQMGTTAITERRHGK------SMDLLLFGAPELAAKLRMKATVQEVEDF 248
            :||:...||::|:..||:.....:   |...      |:.:..|..|.|.| |.:....::|..|
Human   188 SFGVSIDSLNNPQDPFVENTKKLL---RFNPLDPFVLSIKVFPFLTPILEA-LNITVFPRKVISF 248

  Fly   249 YMNIIRDTVDYRVKNNVK-RHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFETSST 312
            ....::...:.|:|...| |.||:.::|:.:...|: :....|:..|:.||:.||..||:||:|:
Human   249 LTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDS-ETHKALSDLELMAQSIIFIFAGYETTSS 312

  Fly   313 TMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHLIRV 377
            .:.|.:||||.|.|:|.|::.||:||| .:.....||::.::.||:.|::||:|..||...|.||
Human   313 VLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERV 376

  Fly   378 ATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFLPFGDGP 442
            ..:..: .|..: |.||..|::|:..:||||:::.|||||:||||.:..........:.|||.||
Human   377 CKKDVE-INGMF-IPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP 439

  Fly   443 RNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK-TVVPLEYRTDDFLLSSK 491
            |||||:||..:.:.:.:..::.||.|:  |.| |.:||:.|....||:.|
Human   440 RNCIGMRFALVNMKLALVRVLQNFSFK--PCKETQIPLKLRFGGLLLTEK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	158/473 (33%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	158/473 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.720