DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a20 and cyp3a4.1

DIOPT Version :9

Sequence 1:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_002943949.2	Gene:	cyp3a4.1 / 100494419	XenbaseID:	XB-GENE-984218	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	166/516 - (32%)
Similarity:	257/516 - (49%)	Gaps:	66/516 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPY-GNTSELMKTVHFADI--FKRTYNKLR 64
            ::.|||:.::.:..|    .:..:|:.|||...| :|: |...|..|.:...||  ||: |.::.
Frog    14 LLAVLLVLILLYGIW----PYGLFKKMGIPGPTP-LPFIGTFLEFRKGMIQFDIECFKK-YGRMW 72

  Fly    65 NKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIRE-FDKFHDRGVFHNERDDPLSANLVNIDGQKWK 128
            ...||.        :.::.:.|....||:|::| :..|.:|..|  ..:.||.:.:...:.::||
Frog    73 GMYDGR--------QPVLAIMDPAIIKTILVKECYTNFTNRRNF--GLNGPLESAITVAEDEQWK 127

  Fly   129 TLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEIT-NVVARFTADVIGSCAFG 192
            .:|..|:|||||||:|.||..:....|.|::  ....|.|.|....| :|:..::.|||.|.:|.
Frog   128 RIRSVLSPTFTSGKLKEMFQIMKDYSDILVK--NVQVSVDKDEPCATKDVIGAYSMDVITSTSFS 190

  Fly   193 LDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAP------------ELAAKLRMKATVQEV 245
            ::..||.:|...||          .|.|::....|.:|            .:...|.:....::.
Frog   191 VNIDSLQNPSNPFV----------IHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDF 245

  Fly   246 EDFYMNIIRDTVDYRVKNNVKRHD-FVDMLIEMKLKFDNGDKE--------NGLTFNEIAAQAFI 301
            ..|:||.:   ..:|.|.....|. .||:|   :|..|:|..|        ..||..||.||:.|
Frog   246 TQFFMNAV---TSFREKRKKGDHSGRVDLL---QLMVDSGTTEGNDSSNQHKALTDAEIMAQSLI 304

  Fly   302 FFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMR 366
            |..||:||:||.:.:..|.||.|.|:|.||..||::.|.. .....||.:.:|.||:.||.||:|
Frog   305 FIFAGYETTSTALSYLFYNLATHPDVQQKLHEEIDSFLPD-KASPTYDILMQMEYLDMVIQETLR 368

  Fly   367 KRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRP 431
            ..|..|.|.||:.|:.:...  .:|.|||..::|...:..|||::||||:|.||||.::....:.
Frog   369 LFPPAGRLERVSKQNVEING--VSIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQT 431

  Fly   432 ACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHP-TKTVVPLEYRTDDFLLSSK 491
            ..|||||||||||||||||..:.:.|.:|.|:.|  |...| .:|::|:|:.|...|...|
Frog   432 PFTFLPFGDGPRNCIGLRFALLSMKVAIATLLQN--FSVRPCAETLIPMEFSTIGVLQPKK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	159/487 (33%)
cyp3a4.1	XP_002943949.2	p450	39..496	CDD:365848	159/487 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2234
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060