Protein Alignment Cyp6a9 and ERG11

DIOPT Version :9

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 515
• Identity: 118/515 - (22%)
• Similarity: 187/515 - (36%)
• Gaps: 141/515 - (27%)

  Fly    55 FSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQ 119
            ::.:|...|:..:...|.. |||....|..|       :..:|.:..|        .|.....|.
Yeast    41 YNIVWQLLYSLRKDRPPLV-FYWIPWVGSAV-------VYGMKPYEFF--------EECQKKYGD 89

  Fly   120 LFLLDGQKWKSMRSKLSYTFTSGKMK-YMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTT 183
            :|              |:......|. |:.|.    ||||  ||.   .|...|......|..||
Yeast    90 IF--------------SFVLLGRVMTVYLGPK----GHEF--VFN---AKLADVSAEAAYAHLTT 131

  Fly   184 DVIGTCAFGI--ECSSLKDPEAE--------------------------FRVMGRRAIFEQRHGP 220
            .|.|.   |:  :|.:.:..|.:                          ||......:.|:..|.
Yeast   132 PVFGK---GVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGT 193

  Fly   221 IGI--------AFINSFQNLARRLHMKITLEEA----------------------EHF------- 248
            |.:        .|..|...|.:.:..|:..:.|                      ||:
Yeast   194 IDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQ 258

  Fly   249 ------FLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFG 307
                  ::.:::|.   |:.|:|:..|.:|.|  :|||...     :.|.:|.:|:|........
Yeast   259 KAISGTYMSLIKER---RKNNDIQDRDLIDSL--MKNSTYK-----DGVKMTDQEIANLLIGVLM 313

  Fly   308 AGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYT 372
            .|..||:.|..:.|..||:..|:|..:.:|...|:.....|:||:.:::|..|:|.|.||||::.
Yeast   314 GGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHH 378

  Fly   373 VLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTF-----NPDNFSPERVK 432
            .|..|.|:.::|..|| :..|||..|..||:..|..|..::.:.|.:.|     |.|:.|...|.
Yeast   379 PLHSLFRKVMKDMHVP-NTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVG 442

  Fly   433 ER-----------DSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIP 481
            |.           .|..:||||.|...|||..|...|....:::.|...|:...|..|:|
Yeast   443 EEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVP 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	118/515 (23%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	107/457 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I1492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1477
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960