DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	557	Identity:	146/557 - (26%)
Similarity:	251/557 - (45%)	Gaps:	103/557 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVYSVLLA--IVVVLVG--YLL---LKWRRALH-----------------YW--QNLDIPCEEP 39
            :|::.|..:  ::::|||  :||   |.|..|.:                 :|  |.:..|.||.
Human     9 LGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEG 73

  Fly    40 HILMGSLTGVQTSRSFSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTD 104
            ..::..|  |.|......:||         ||.:.......|.|:...|:.:..|..|      |
Human    74 MRVLTQL--VATYPQGFKVWM---------GPISPLLSLCHPDIIRSVINASAAIAPK------D 121

  Fly   105 RGFYHNTEDDPLSGQ-LFLLDGQKWKSMRSKLSYTFTSGKMK-YMFPTVVKVGHEFIEVFGQ--- 164
            :.||...|  |..|. |.|..|.||...|..|:..|....:| ||     |:.:|.:.:...
Human   122 KFFYSFLE--PWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYM-----KIFNESVNIMHAKWQ 179

  Fly   165 --AMEKSPIVEVRDILARFTTDVIGTCAFGIECSSLKDPEAEF--RVMGRRAIFEQRHGPI--GI 223
              |.|.|..:::.:.::..|.|.:..|.|..: |..::..:|:  .::...|:..:||..|  .|
Human   180 LLASEGSACLDMFEHISLMTLDSLQKCVFSFD-SHCQEKPSEYIAAILELSALVSKRHHEILLHI 243

  Fly   224 AFI-------NSFQNLARRLH--MKITLEEAEHFFLRIVRETVA-------FREKNNIRRNDFMD 272
            .|:       ..|:...|.:|  ....::|.        |.|:.       .:.|...:..||:|
Human   244 DFLYYLTPDGQRFRRACRLVHDFTDAVIQER--------RRTLPSQGVDDFLQAKAKSKTLDFID 300

  Fly   273 QLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKE 337
            .|:      |:|.|.|:  .|:.|::.|:|..|...|.:|:::.:.:.||.||:|.:.|:|.|:|
Human   301 VLL------LSKDEDGK--KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQE 357

  Fly   338 CQEVI-GKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMP 400
            .||:: .:...||.::.:..:.:|...:.|:|||:..:||::|...:|..:| |.   ||.||:.
Human   358 VQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGR---VIPKGII 419

  Fly   401 VLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLAL 465
            .||.....|.:..::.:|..::|..|.||.:|||..:.::||..|||||||..|...:.:..|||
Human   420 CLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLAL 484

  Fly   466 LINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            .:.||:  |....|.|  ..|...::.:|.|::|:||
Human   485 TLLRFR--VLPDHTEP--RRKPELVLRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	131/492 (27%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	10/47 (21%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	133/510 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810