DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp20a1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_084289.1	Gene:	Cyp20a1 / 77951	MGIID:	1925201	Length:	462	Species:	Mus musculus

Alignment Length:	478	Identity:	115/478 - (24%)
Similarity:	201/478 - (42%)	Gaps:	84/478 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEF 99
            |.||..   |:|..:..|.|.....::.:.::   ||...| ||.|.    |.:||....::|:.
Mouse    37 PTEEKD---GNLPDIVNSGSLHEFLVNLHERY---GPVVSF-WFGRR----LVVSLGTTDVLKQH 90

  Fly   100 NKFTDRGFYHNTEDDPLSGQLFLLDGQKWKS---------MRSKLSYTFTSGKMKYMFPTVVKVG 155
                   |..|...||....|..|.|  ::|         :|.||.....:..:...||.::::.
Mouse    91 -------FNPNKTSDPFETMLKSLLG--YQSGGGSAGEDHVRRKLYGDAVTASLHSNFPLLLQLS 146

  Fly   156 HEFIEVFGQAMEKSPIVEVRDILA---RFTTD-VIGTCAFGIECSSLKDPEAEFRVMGRRAIFEQ 216
            .|.::.:....|...|...:.:|.   :|.|. |:|        |:.:|.:...|       |::
Mouse   147 EELLDKWLSYPETQHIPLSQHMLGFALKFVTRMVLG--------STFEDEQEVIR-------FQK 196

  Fly   217 RHG----PIGIAFINSF--QNLARRLHMKITLEEAEHFFLRIVRETVAFREKNNIRRNDFMDQLI 275
            .||    .||..|::..  :|..|:...:..|.:.|....:|::|    |:..|.|::.|:|.|.
Mouse   197 IHGTVWSEIGKGFLDGSLDKNTTRKKQYQEALMQLESTLKKIIKE----RKGGNFRQHTFIDSLT 257

  Fly   276 DLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQE 340
            ..|              |..:::.....||..|....::....:.::.|....::|.::.||..:
Mouse   258 QGK--------------LNEQQILEDCVVFSLASCIITARLCTWTIHFLTTTGEVQKKLCKEIDQ 308

  Fly   341 VIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPC 405
            |:|:  |.||.|.::.:.|..||:.||:|...:.||..|  |:|.|....| :||.|...||...
Mouse   309 VLGE--GPITSEKIEQLSYCQQVLFETVRTAKLTPVSAR--LQDIEGKVGP-FVIPKETLVLYAL 368

  Fly   406 GAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRF 470
            |.:.:|...:..|:.|:||.|:.|.|.:..|.  |.| .|...|..:||..|.....:::|:.|.
Mouse   369 GVVLQDPSTWPLPHRFDPDRFADEPVMKVFSS--LGF-SGTWECPELRFAYMVTAVLVSVLLKRL 430

  Fly   471 KFSVCEQTTIPIVYSKKTFLISS 493
            :....::.    |:..|..|::|
Mouse   431 RLLAVDRQ----VFEMKYELVTS 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	115/478 (24%)
Cyp20a1	NP_084289.1	p450	43..446	CDD:299894	110/464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7447
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860