Protein Alignment Cyp6a9 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 139/552 - (25%)
• Similarity: 243/552 - (44%)
• Gaps: 111/552 - (20%)

  Fly     8 LAIVVVLVGYLL---LKWRRALH-----------------YWQNLDI--PCEEPHILMGSLTGVQ 50
            |.:::|:..:||   |.|..|.:                 :|.:|.:  |.||     |.....|
Human    20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEE-----GLKNSTQ 79

  Fly    51 TSRSFS---AIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKE--FNKFTDRGFYHN 110
            .|.::|   .:|:         ||...|.....|..:....:.:..|..|:  |.:|.
Human    80 MSATYSQGFTVWL---------GPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFL------- 128

  Fly   111 TEDDPLSGQLFLLD-GQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQ---------- 164
               .|..|:..||. |.||...|..|:..|....:|           .:|.:|.:
Human   129 ---KPWLGEGILLSGGDKWSRHRRMLTPAFHFNILK-----------SYITIFNKSANIMLDKWQ 179

  Fly   165 --AMEKSPIVEVRDILARFTTDVIGTCAFGIECSSLKDPEAEF--RVMGRRAIFEQRHGPI--GI 223
              |.|.|..:::.:.::..|.|.:..|.|..: |..::..:|:  .::...|:.|:|...|  .:
Human   180 HLASEGSSRLDMFEHISLMTLDSLQKCIFSFD-SHCQERPSEYIATILELSALVEKRSQHILQHM 243

  Fly   224 AFINSFQNLARRLHMKITLEEAEHFF----LRIVRETVA-------FREKNNIRRNDFMDQLIDL 277
            .|:....:..||.|....|   .|.|    :|..|.|:.       |::|...:..||:|.|:
Human   244 DFLYYLSHDGRRFHRACRL---VHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLL-- 303

  Fly   278 KNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVI 342
                |:|.|.|::  |:.|::.|:|..|...|.:|:::.:.:.||.||:|.:.|:|.|:|.||::
Human   304 ----LSKDEDGKA--LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELL 362

  Fly   343 -GKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVLIPC 405
             .:...||.::.:..:.:|...:.|:|||:...|.::|.|.:|..:| |.   ||.||:..||..
Human   363 KDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR---VIPKGITCLIDI 424

  Fly   406 GAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRF 470
            ..:|.:..::.:|..::|..|.||..|.|..:.::||..|||||||..|...:.:..|||::..|
Human   425 IGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489

  Fly   471 KFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            :|  ....|.|  ..|...::.:|.|::|:||
Human   490 RF--LPDHTEP--RRKLELIMRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	119/461 (26%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	123/489 (25%)