DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and CYP20A1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001358624.1	Gene:	CYP20A1 / 57404	HGNCID:	20576	Length:	470	Species:	Homo sapiens

Alignment Length:	496	Identity:	111/496 - (22%)
Similarity:	201/496 - (40%)	Gaps:	91/496 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEF 99
            |.||..   |:|..:..|.|.....::.:.::   ||...| ||.|.    |.:||..:.::|:
Human    37 PTEEKD---GNLPDIVNSGSLHEFLVNLHERY---GPVVSF-WFGRR----LVVSLGTVDVLKQ- 89

  Fly   100 NKFTDRGFYH---NTEDDPLSGQLFLLDGQKWKS---------MRSKLSYTFTSGKMKYMFPTVV 152
                     |   |...||....|..|  .:::|         ||.||.....:..:|..|..::
Human    90 ---------HINPNKTSDPFETMLKSL--LRYQSGGGSVSENHMRKKLYENGVTDSLKSNFALLL 143

  Fly   153 KVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIECSSLKDPEAEFRVMGRRAIFEQR 217
            |:..|.::.:....|...:...:.:|. |....:.....|   |:.:|.:...|       |::.
Human   144 KLSEELLDKWLSYPETQHVPLSQHMLG-FAMKSVTQMVMG---STFEDDQEVIR-------FQKN 197

  Fly   218 HG------------PIGIAFINSF--QNLARRLHMKITLEEAEHFFLRIVRETVAFREKNNIRRN 268
            ||            .||..|::..  :|:.|:...:..|.:.|.....|::|    |:..|..::
Human   198 HGTLCIFTYFQVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIKE----RKGRNFSQH 258

  Fly   269 DFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDR 333
            .|:|.|:              ..||..:::...:.:|..|....::....:|:..|...:::|.:
Human   259 IFIDSLV--------------QGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKK 309

  Fly   334 VRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGH-PKYVIKK 397
            :.:|..:|.|  ||.:|.|.::.:.|...|:.||:|...:.||..:  |:|.|  |. .:::|.:
Human   310 LYEEINQVFG--NGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQ--LQDIE--GKIDRFIIPR 368

  Fly   398 GMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSG 462
            ...||...|.:.:|...:.:|:.|:||.|..|.|.:..|.  |.| .|.:.|..:||..|.....
Human   369 ETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSS--LGF-SGTQECPELRFAYMVTTVL 430

  Fly   463 LALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVER 503
            |::|:.|......|...|...|...|   ||....::.|.:
Human   431 LSVLVKRLHLLSVEGQVIETKYELVT---SSREEAWITVSK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	110/490 (22%)
CYP20A1	NP_001358624.1	p450	43..454	CDD:386267	104/468 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7447
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860