DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	509	Identity:	154/509 - (30%)
Similarity:	264/509 - (51%)	Gaps:	41/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWM---DYYNKFR 67
            |||...:||. |:...:...|  ::.|.||..:|..|:|::...     :..:|.   |.|.|:
Mouse    13 VLLVTSLVLF-YIYGTYSHGL--FKKLGIPGPKPLPLLGTIFNY-----YDGMWKFDEDCYKKY- 68

  Fly    68 GTGPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDP---LSGQLFLLDGQKW 128
              |...|||...:|.:.::|..:.|::|:|| ::.||:|.|:     .|   :...:.:.:.::|
Mouse    69 --GKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFF-----GPVGFMKKAITISEDEEW 126

  Fly   129 KSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGI 193
            |.:|:.||.||||||:|.|||.:.:.|...:....:..||...:.::||...::.|||...:||:
Mouse   127 KRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFGV 191

  Fly   194 ECSSLKDPEAEFRVMGRRAIFEQRHGP--IGIAFINSFQNLARRLHMKITLEEAEHFFLRIV--- 253
            ...||.:|:..|....::.:..:...|  :.|........:...|:..|...::.:||.:.|
Mouse   192 NVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRM 256

  Fly   254 -RETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTM 317
             :|.:|..:||.:   ||:..:::.:||...:|:..    |:..||||||.:|...|::.:||::
Mouse   257 KKERLASNQKNRV---DFLQLMMNTQNSKGQESQKA----LSDLEMAAQAVIFIFGGYDATSTSI 314

  Fly   318 GFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECL 382
            ...:||||.|.|:|.:::.|....:.. ...:||:::.||.|||.|::|:||||.:...|.|...
Mouse   315 SLIMYELATHPDVQKKLQDEIDRTLPN-KAPVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSK 378

  Fly   383 EDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPR 447
            :|.|:.|   ..|.||..|:||...:||:.:.:..|..|.|:.||.|.....|...::|||:|||
Mouse   379 KDVEING---VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGNGPR 440

  Fly   448 NCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501
            |||||||..:..:..:..::..|....||:|.||:..|::. :...|..|.|||
Mouse   441 NCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREP-IFQPEKPIILKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	142/476 (30%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	143/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720