DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	119/469 - (25%)
Similarity:	213/469 - (45%)	Gaps:	67/469 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GTGPFAGFYWFQRPGILVLDISLAKLILIKEFNK------FTDRGFYHNTEDDPLSGQ-LFLLDG 125
            ||.|.....|.   |.:|..|:|....:::....      ..|..||  |...|..|. |.:..|
  Rat    82 GTYPQGFLMWI---GPMVPVITLCHSDIVRSILNASAAVALKDVIFY--TILKPWLGDGLLVSAG 141

  Fly   126 QKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQA------------MEKSPIVEVRDIL 178
            .||...|..|:..|....:|           .::::|..:            .|.|..:::.:.:
  Rat   142 DKWSRHRRMLTPAFHFNILK-----------PYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHV 195

  Fly   179 ARFTTDVIGTCAFGIECSSLKDPEAEF--RVMGRRAIFEQRHGPIGIAFINSFQNL---ARRLHM 238
            :..|.|.:..|.|..: |:.::..:|:  .::...|:..:||.. .:.|::...||   ..|.|.
  Rat   196 SLMTLDSLQKCVFSFD-SNCQEKSSEYIAAILELSALVAKRHQQ-PLLFMDLLYNLTPDGMRFHK 258

  Fly   239 KITL-EEAEHFFLRIVRETVA-------FREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTI 295
            ...| .|.....:|..|.|:.       .:.|...:..||:|.|:      |||.|.|:  .|:.
  Rat   259 ACNLVHEFTDAVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLL------LTKDEDGK--ELSD 315

  Fly   296 EEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVI-GKYNGEITYESMKDMVY 359
            |::.|:|..|...|.:|:::.:.:.||.||:|.:.|:|.|:|.||:: .:...||.::.:..:.:
  Rat   316 EDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPF 380

  Fly   360 LDQVISETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNP 423
            |...|.|:|||:..:.|::|.|.:|..:| |.   .|.||:..||....:|.:..::.:|..:||
  Rat   381 LTMCIKESLRLHPPVTVISRCCTQDILLPDGR---TIPKGIICLISIFGIHHNPSVWPDPEVYNP 442

  Fly   424 DNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKT 488
            ..|.||.:|:...:.::||..|||||||..|...:.:..|||.:.||:....::..    ..:..
  Rat   443 FRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEP----RRQPE 503

  Fly   489 FLISSETGIFLKVE 502
            .::.:|.|::|:||
  Rat   504 LILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	116/464 (25%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	116/465 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900