DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	510	Identity:	143/510 - (28%)
Similarity:	260/510 - (50%)	Gaps:	38/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTGPF 72
            ||.::|:.|    .|..  .|::.|.||..:.....|::  ::....|....||.:.|:   |..
Zfish    14 LAALLVIYG----SWPH--RYFKKLGIPGPKAIPFFGTM--LRYKDGFHVFDMDCFEKY---GRI 67

  Fly    73 AGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDPLSGQLF----LLDGQKWKSMR 132
            .|.|..::|.:.::|.::.|.:|||| ::.||:|..:.      |:|.|:    :.:...|:.:|
Zfish    68 WGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFR------LNGALYDAVSIAEDDDWRRIR 126

  Fly   133 SKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIECSS 197
            |.||.:||||::|.||..:.|..|..::..|:..::....::::....::.||:.:.||.::..|
Zfish   127 SVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDVVTSTAFSVDIDS 191

  Fly   198 LKDPEAEFRVMGRRAIFEQRHGPIG--IAFINSFQNLARRLHMKITLEEAEHFF------LRIVR 254
            |.:|:..|....::.:......|:.  |||......:..::...:.......||      ::..|
Zfish   192 LNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDR 256

  Fly   255 ETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESV--NLTIEEMAAQAFVFFGAGFETSSTTM 317
            :|....:.|..:|.||:..::|.:.....||: ||..  .|:..|:.:|:.:|..||:||||:|:
Zfish   257 DTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSD-GEHTEKGLSDHEILSQSMIFIFAGYETSSSTL 320

  Fly   318 GFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECL 382
            .|..|.||.:.:...::::|..|.... ...:.||::..|.|||..:||:|||:.|...|.|.|.
Zfish   321 SFLFYNLATNPETMKKLQEEIDETFPN-QAPVDYETLMSMDYLDAALSESLRLFPVAARLERVCK 384

  Fly   383 EDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPR 447
            :..|:.|   .:|.|.:.|::|..|:|||...::.|.:|.|:.|:....:..|...::|||.|||
Zfish   385 KTVEING---LLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPR 446

  Fly   448 NCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            |||||||.|:..:..:..::.||..|||::|.:|:...... |:|.:..|.||::
Zfish   447 NCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNG-LLSPKDPIKLKLQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	133/478 (28%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	134/480 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820