DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	482	Identity:	136/482 - (28%)
Similarity:	247/482 - (51%)	Gaps:	21/482 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTGPF 72
            |..:|:.:.|:...|...  :::.|.||...|....|  |.:..::.|....|:...|:   |..
Zfish    13 LVFLVITLLYMYGVWPHG--FFKKLGIPGPRPWPFFG--TFLSYTKGFFNFDMECAKKY---GKV 70

  Fly    73 AGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSMRSKLS 136
            .|.|..:.|.::|.|:.:.|.|::|| ::.||:|...:.....||:..:..:..::||.:|..||
Zfish    71 WGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWKRIRGTLS 135

  Fly   137 YTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIECSSLKDP 201
            ..||||::|.:||..:.....||:...:...:.| |::::::|.::.||:.:.:|.::..|:.:|
Zfish   136 PYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQP-VKIKEVVAPYSLDVVTSSSFSVDIDSINNP 199

  Fly   202 EAEFRVMGRRAIFEQRHGPIGIAFIN---SFQNLARRLHMKITLEEAEHFFLRIVRETVAFREKN 263
            :..|....:..:......|: |.|:.   |..||..::.:.:......:||...:|: :....|:
Zfish   200 DDPFVTNIKNFLKFSLFSPL-ILFLTLFPSIANLLGKMGISVFSRSIMNFFYTALRK-IKDEHKD 262

  Fly   264 NIRRNDFMDQLI--DLKNSPLTKSESGESV-NLTIEEMAAQAFVFFGAGFETSSTTMGFALYELA 325
            :..|.||:..:|  .:.:.....:.|.:.| .||..|:.:|:|:|...|:||:|||:.|.|:.||
Zfish   263 SNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGGYETTSTTLSFLLHNLA 327

  Fly   326 QHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGH 390
            .:.|..:::.:|..:.. ..:..|:|:::..|.||:..|:|::||....|.|.|.|.:..|:.|
Zfish   328 TNPDCLEKLVEEIDKNF-PLDTPISYDALMKMDYLEMSINESMRLLPTAPRLERVCKKTVELNG- 390

  Fly   391 PKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFG 455
              ..|.|...|.||...::||.:|:.:|..|.|:.||||...|.....::|||.||||||||||.
Zfish   391 --ITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRFA 453

  Fly   456 QMQARSGLALLINRFKFSVCEQTTIPI 482
            .|..:..:..|:..|....|::|.||:
Zfish   454 LMIVKLLVVKLLQNFSLETCKETQIPL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	130/455 (29%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	130/455 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720