DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	162/519 - (31%)
Similarity:	275/519 - (52%)	Gaps:	44/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VYSVLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSL-TGVQTSRSFSAIWMDYYNKF 66
            ::::||.|::  .|.|....:|...:||.|.:..|...|..|.: |.::..||......|.|  .
  Fly     1 MWTILLTILI--AGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIY--A 61

  Fly    67 RGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSM 131
            |..|...|.|...:..||:.|..||:.|:..:|..|.|||.|.:.:.||||..||.|.|..|:::
  Fly    62 RHEGKIVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNL 126

  Fly   132 RSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIECS 196
            |.||:.:|:|||:|.||.|:..||.:.::....|:::|..||::|::..:..|:||:..||:|..
  Fly   127 RQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEID 191

  Fly   197 SLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLA-------RRLHMKITLEEAEHFFLR-IV 253
            |.::|:.|||.:......::       :.:....|::       .:|..::..|......|| ::
  Fly   192 SFRNPKNEFREISSSTSRDE-------SLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMM 249

  Fly   254 RETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGES--------------VNLTIEEMAAQAFV 304
            :.|:.|||::|:.|.|.:..||.|:|:    .:.||.              .:::||::|||||:
  Fly   250 KRTIEFREEHNVVRKDMLQLLIRLRNT----GKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFL 310

  Fly   305 FFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYN----GEITYESMKDMVYLDQVIS 365
            |:.||.|:::....|.||||:.:.::....::|...|:.|:|    ...|||:::|:.:||..|.
  Fly   311 FYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIM 375

  Fly   366 ETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPER 430
            ||:|.|..||.|||||.|||.||| ..::|.||.|:||....|.||...:.|||.::|..|....
  Fly   376 ETIRKYPGLPFLNRECTEDYPVPG-TNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNN 439

  Fly   431 VKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSE 494
            : ..|...::|||:|||:||.:|.|::.::..:|.::..|......:..:...:.....|::.|
  Fly   440 M-NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	153/487 (31%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	144/451 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461160
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900