DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp317a1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	175/517 - (33%)
Similarity:	285/517 - (55%)	Gaps:	36/517 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VYSVLLAIVVVLVGYLLL-----KWRRALHYWQNLDIPCEEPHILMGSLTGVQT---------SR 53
            ::.:.|.|.::::|.|:|     :::|  .||:.||||.|.|..|...:..:.|         :.
  Fly     1 MWIIFLIIGLLVLGLLVLLIIAARYQR--DYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAE 63

  Fly    54 SFSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSG 118
            .:|||    |.||:|:|||.|||...:|..|:||..|.:.|:||:|..|.|||.|.|.:.|||||
  Fly    64 HYSAI----YKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSG 124

  Fly   119 QLFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSP--IVEVRDILARF 181
            .|:.|.|:.||.||.||..:....:|..::..:.:...:.:......:...|  .|.::.|:.|:
  Fly   125 DLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRY 189

  Fly   182 TTDVIGTCAFGIECSSLKD-PEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEA 245
            ....:..|.||:.....|. |..:|..|...|:...:||.:....:..|.|..|.|.|:.|.::|
  Fly   190 VLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQA 254

  Fly   246 EHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLT--KSESGESVNLTIE-EMAAQAFVFFG 307
            |.:|::::...|..||.:...:.|::..|||:|.....  :.|:.:.:...:: |:||.|.||..
  Fly   255 EEYFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLK 319

  Fly   308 AGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYT 372
            ||:|.::.|:.:.|||||.|.::|.|||:|.::.|.:::|.||:|.:|.:.::.|||:||||::.
  Fly   320 AGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHP 384

  Fly   373 VLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSV 437
            :.|.:.|..|.||.||.||||::.|.:.::||..|:|.|..:|.:|..|.||.:|..|...::..
  Fly   385 ITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQG 449

  Fly   438 EWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFL 499
            .|..||.|.|:|||::|.|:|.|..||||::.::||:  .|..|        ||:.|.||.|
  Fly   450 TWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSL--NTRKP--------LINLEDGIAL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	163/478 (34%)
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	144/430 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471840
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900