DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	146/519 - (28%)
Similarity:	252/519 - (48%)	Gaps:	31/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALH-YWQNLDIPCEEPHILMGSLT------GVQTSRSFSAIWMDYY 63
            :.||:.::|: .||.||..|.: .:....:..|:|..|:|::.      |:...:..    ::.:
  Fly     6 IALALFIILL-VLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKM----IELH 65

  Fly    64 NKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNT-EDDPLSGQLFLLDGQK 127
            .|..|: |..|.|..:.....|.|..|.|||.||||:.|.:....||. ::..||..|..|...:
  Fly    66 TKHTGS-PVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGR 129

  Fly   128 WKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFI----EVFGQAMEKSPIVEVRDILARFTTDVIGT 188
            ||.||:.|:..||..||:.|:..:.....|.:    |....:.:.|..:|::|...||..|||.|
  Fly   130 WKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIAT 194

  Fly   189 CAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFLRIV 253
            .||||..:|.:..:.||..:|:..........:.......|..|.:.|.:::...:...:|..:|
  Fly   195 VAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLV 259

  Fly   254 RETVAFREKNNIRRNDFMDQLIDLKNSPL------TKSESGESVNLTIEEMAAQAFVFFGAGFET 312
            ...:.:|:::.:.|.|.:..|::.|...|      :|.|...| ..|.:::.||..:||.||||.
  Fly   260 TAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYS-EFTADDLLAQCLLFFFAGFEI 323

  Fly   313 SSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGE-ITYESMKDMVYLDQVISETLRLYTVLPV 376
            .|:::.|..:||..:..:|||:.:|...|..:..|: :||:.:..|.|||.|:.|.||.:.....
  Fly   324 ISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPSIS 388

  Fly   377 LNRECLED---YEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVE 438
            .:|||.:|   ::..|...:..:||..:.||..::|.|.:.:.:|..|||:.|:.....|  |..
  Fly   389 TDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGHALE--SRV 451

  Fly   439 WLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            ::|||.|||||||.|...|:.:|.:..|:..||....::|:..::...:...:..:.|.:||.|
  Fly   452 YMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGFWLKFE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	135/484 (28%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	134/481 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461220
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800